A new synthetic analogue of thymidine, 7-(3-bromo-phenoxy)-thymidine, inhibits the proliferation of tumor cells

Kyung Noo Kim, Jiyong Lee, Dong Hoon Kim, Jong Shin Yoo, Ho Jeong Kwon

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The synthesis of new thymidine analogues and their biological activities are described. Modified thymidine analogues have been highlighted as useful agents for the treatment of cancer and viral diseases due to their potent biological activities. In the present study, we synthesized a new thymidine analogue, 7-(3-bromo-phenoxy)-thymidine (4a), as a potential lead for anti-tumor agent. Compound 4a potently inhibits HeLa cell proliferation with an IC 50 of 15 μM.

Original languageEnglish
Pages (from-to)77-79
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number1
DOIs
Publication statusPublished - 2005 Jan 3

Bibliographical note

Funding Information:
This study was supported by the National Research Laboratory Grant from the Ministry of Science and Technology, Republic of Korea and the Brain Korea 21 Project.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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