6,7-Dichloro-5,8-quinoxalinedione (2), an analogue of Dichlone®, was prepared from 4-aminophenol (3) in 27% overall yield in 8 steps via chloroxidation of the sulfuric acid salt of 8-amino-5-quinoxalinol (9) as a key step. And two derivatives, 6-chloro-5-hydroxypyrazino[2,3-a]phenazine (10) and pyrido[1,2-a]imidazo[4,5-g]quinoxaline-6,11-dione (11), were prepared by reaction of 2 with 1,2-phenylenediamine and 2-aminopyridine in 79% and 46% yields, respectively.
|Number of pages||7|
|Publication status||Published - 1996 Dec 1|
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Organic Chemistry