A nomogram constructed using intraoperative ex vivo shear-wave elastography precisely predicts metastasis of sentinel lymph nodes in breast cancer

Soong June Bae, Ji Hyun Youk, Chang Ik Yoon, Soeun Park, Chi Hwan Cha, Hak Woo Lee, Sung Gwe Ahn, Seung Ah Lee, Eun Ju Son, Joon Jeong

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To develop a nomogram and validate its use for the intraoperative evaluation of nodal metastasis using shear-wave elastography (SWE) elasticity values and nodal size Methods: We constructed a nomogram to predict metastasis using ex vivo SWE values and ultrasound features of 228 axillary LNs from fifty-five patients. We validated its use in an independent cohort comprising 80 patients. In the validation cohort, a total of 217 sentinel LNs were included. Results: We developed the nomogram using the nodal size and elasticity values of the development cohort to predict LN metastasis; the area under the curve (AUC) was 0.856 (95% confidence interval (CI), 0.783–0.929). In the validation cohort, 15 (7%) LNs were metastatic, and 202 (93%) were non-metastatic. The mean stiffness (23.54 and 10.41 kPa, p = 0.005) and elasticity ratio (3.24 and 1.49, p = 0.028) were significantly higher in the metastatic LNs than those in the non-metastatic LNs. However, the mean size of the metastatic LNs was not significantly larger than that of the non-metastatic LNs (8.70 mm vs 7.20 mm, respectively; p = 0.123). The AUC was 0.791 (95% CI, 0.668–0.915) in the validation cohort, and the calibration plots of the nomogram showed good agreement. Conclusions: We developed a well-validated nomogram to predict LN metastasis. This nomogram, mainly based on ex vivo SWE values, can help evaluate nodal metastasis during surgery. Key Points: • A nomogram was developed based on axillary LN size and ex vivo SWE values such as mean stiffness and elasticity ratio to easily predict axillary LN metastasis during breast cancer surgery. • The constructed nomogram presented high predictive performance of sentinel LN metastasis with an independent cohort. • This nomogram can reduce unnecessary intraoperative frozen section which increases the surgical time and costs in breast cancer patients.

Original languageEnglish
Pages (from-to)789-797
Number of pages9
JournalEuropean Radiology
Volume30
Issue number2
DOIs
Publication statusPublished - 2020 Feb 1

Bibliographical note

Funding Information:
This work was supported by a grant from the research fund of Yonsei University Medical College, Seoul, Republic of Korea (6-2014-0199).

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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