A novel and efficient approach to highly substituted indolizines via 5-endo-trig iodocyclization

Ikyon Kim, Hye Kyoung Won, Jihyun Choi, Ge Hyeong Lee

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38 Citations (Scopus)

Abstract

A new approach to indolizines has been developed using a 5-endo-trig iodocyclization of allylic esters followed by isomerization and dehydroiodination facilitated by triethylamine at rt. This mild procedure enabled us to synthesize a number of highly substituted indolizines in good yields.

Original languageEnglish
Pages (from-to)12954-12960
Number of pages7
JournalTetrahedron
Volume63
Issue number52
DOIs
Publication statusPublished - 2007 Dec 24

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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