A new approach to indolizines has been developed using a 5-endo-trig iodocyclization of allylic esters followed by isomerization and dehydroiodination facilitated by triethylamine at rt. This mild procedure enabled us to synthesize a number of highly substituted indolizines in good yields.
Bibliographical noteFunding Information:
We thank the Center for Biological Modulators and Korea Research Institute of Chemical Technology for generous financial support.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry