A novel approach to 3-acylated indolizine structures via iodine-mediated hydrative cyclization

Ikyon Kim, Sun Gi Kim, Ji Young Kim, Ge Hyeong Lee

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

We have discovered a new route to 3-acylated indolizine structures via iodine-mediated hydrative cyclization. Reaction mechanism is proposed for this novel transformation, which involves a 5-exo-dig iodocyclization, deprotonation, incorporation of another iodo group, deprotonation, and subsequent replacement of the diiodo group by H2O. Various 3-acylated indolizine derivatives were obtained using this mild procedure in good yields.

Original languageEnglish
Pages (from-to)8976-8981
Number of pages6
JournalTetrahedron Letters
Volume48
Issue number51
DOIs
Publication statusPublished - 2007 Dec 17

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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