TY - GEN
T1 - A novel cancer classifier based on differentially expressed gene network
AU - Ahn, Jaegyoon
AU - Yoon, Youngmi
AU - Park, Sanghyun
PY - 2010
Y1 - 2010
N2 - It is fundamental and essential to elucidate how cancerrelated genes interact with each other. In this study, we build two undirected graphs: one is a graph consisting of edges only observed in tumor samples, and the other is a graph consisting of edges only observed in normal samples. We apply a genetic algorithm for searching sub-networks of these genetic networks. Those gene sub-networks identify new cancer-related genes that might be related with previously known cancer-related genes, and also show a higher accuracy in classifying tumor and normal samples than the current methods.
AB - It is fundamental and essential to elucidate how cancerrelated genes interact with each other. In this study, we build two undirected graphs: one is a graph consisting of edges only observed in tumor samples, and the other is a graph consisting of edges only observed in normal samples. We apply a genetic algorithm for searching sub-networks of these genetic networks. Those gene sub-networks identify new cancer-related genes that might be related with previously known cancer-related genes, and also show a higher accuracy in classifying tumor and normal samples than the current methods.
UR - http://www.scopus.com/inward/record.url?scp=77958027192&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77958027192&partnerID=8YFLogxK
U2 - 10.1145/1854776.1854868
DO - 10.1145/1854776.1854868
M3 - Conference contribution
AN - SCOPUS:77958027192
SN - 9781450304382
T3 - 2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010
SP - 493
EP - 495
BT - 2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010
T2 - 2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010
Y2 - 2 August 2010 through 4 August 2010
ER -
