A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model

Hyeon Jeong Kim, Bo Ko Jang, Jong Hyun Park, Ji Won Choi, Sun Jun Park, Seong Rim Byeon, Ae Nim Pae, Yong Sup Lee, Eunji Cheong, Ki Duk Park

Research output: Contribution to journalArticle

Abstract

Alzheimer's disease is a common neurodegenerative disease characterized by progressive degeneration and neuronal cell death, resulting in neural network dysfunction. As the underlying mechanisms, oxidative damage and neuroinflammation have been reported to contribute to the onset and deterioration of Alzheimer's disease. The nuclear factor E2-related factor 2-antioxidant responsive element signaling pathway is a pivotal cellular defense mechanism against oxidative stress. Nrf2, a transcription factor, regulates the cellular redox balance and is primarily involved in anti-inflammatory responses. In this study, we synthesized novel chalcone derivatives and found a highly potent Nrf2 activator, compound 20a. Compound 20a confirmed to activate Nrf2 and induce expression of the Nrf2-dependent enzymes HO-1 and GCLC at both mRNA and protein levels. It also suppressed the production of nitric oxide and downregulated inflammatory mediators in BV-2 microglial cells. We found that compound 20a effectively increased the expression level and the activity of superoxide dismutase in both BV-2 microglial cells and brain hippocampus region of the scopolamine-induced mouse model. In addition, compound 20a effectively recovered the learning and memory impairment in a scopolamine-induced mouse model.

Original languageEnglish
Article number111777
JournalEuropean Journal of Medicinal Chemistry
Volume185
DOIs
Publication statusPublished - 2020 Jan 1

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Chalcone
Scopolamine Hydrobromide
Alzheimer Disease
NF-E2-Related Factor 2
Learning
Neurodegenerative diseases
Derivatives
Data storage equipment
Oxidative stress
Cell death
Defense Mechanisms
Neurodegenerative Diseases
Superoxide Dismutase
Oxidation-Reduction
Deterioration
Hippocampus
Brain
Nitric Oxide
Oxidative Stress
Cell Death

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

Kim, Hyeon Jeong ; Jang, Bo Ko ; Park, Jong Hyun ; Choi, Ji Won ; Park, Sun Jun ; Byeon, Seong Rim ; Pae, Ae Nim ; Lee, Yong Sup ; Cheong, Eunji ; Park, Ki Duk. / A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model. In: European Journal of Medicinal Chemistry. 2020 ; Vol. 185.
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A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model. / Kim, Hyeon Jeong; Jang, Bo Ko; Park, Jong Hyun; Choi, Ji Won; Park, Sun Jun; Byeon, Seong Rim; Pae, Ae Nim; Lee, Yong Sup; Cheong, Eunji; Park, Ki Duk.

In: European Journal of Medicinal Chemistry, Vol. 185, 111777, 01.01.2020.

Research output: Contribution to journalArticle

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