A novel effect of rebamipide: Generation of [Ca 2+ ](i) oscillations through activation of CCK 1 receptors in rat pancreatic acinar cells

Seok Jun Moon, Wooin Ahn, Min Goo Lee, Hye Young Kim, Syng Ill Lee, Jeong Taeg Seo, R. Maynard Case, Kyung Hwan Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The protective effect of 2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]-propionic acid (rebamipide) on gastric mucosa is well established. Here we demonstrate that rebamipide acts on pancreatic acinar cells to generate oscillations of intracellular Ca 2+ concentration ([Ca 2+ ](i)) through the activation of cholecystokinin subtype 1 (CCK 1 ) receptors. At concentrations higher than 5 μM, rebamipide induced [Ca 2+ ](i) oscillations in individual fura-2-loaded pancreatic acinar cells. The frequency of oscillations increased with increasing concentrations of rebamipide, while the latency between stimulation of cells and initiation of [Ca 2+ ](i) oscillations decreased with increasing concentration. The [Ca 2+ ](i) oscillations evoked by rebamipide were inhibited by the CCK 1 receptor antagonist L-364,718 but not by atropine or the CCK 2 receptor antagonist L-365,260 indicating that rebamipide is a nonpeptide CCK 1 receptor agonist. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalEuropean Journal of Pharmacology
Volume388
Issue number1
DOIs
Publication statusPublished - 2000 Jan 24

Fingerprint

Cholecystokinin A Receptor
Cohort Effect
Acinar Cells
Cholecystokinin
Devazepide
Cholecystokinin Receptors
Fura-2
Gastric Mucosa
rebamipide
Atropine

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Moon, Seok Jun ; Ahn, Wooin ; Lee, Min Goo ; Kim, Hye Young ; Lee, Syng Ill ; Seo, Jeong Taeg ; Case, R. Maynard ; Kim, Kyung Hwan. / A novel effect of rebamipide : Generation of [Ca 2+ ](i) oscillations through activation of CCK 1 receptors in rat pancreatic acinar cells. In: European Journal of Pharmacology. 2000 ; Vol. 388, No. 1. pp. 17-20.
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A novel effect of rebamipide : Generation of [Ca 2+ ](i) oscillations through activation of CCK 1 receptors in rat pancreatic acinar cells. / Moon, Seok Jun; Ahn, Wooin; Lee, Min Goo; Kim, Hye Young; Lee, Syng Ill; Seo, Jeong Taeg; Case, R. Maynard; Kim, Kyung Hwan.

In: European Journal of Pharmacology, Vol. 388, No. 1, 24.01.2000, p. 17-20.

Research output: Contribution to journalArticle

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AU - Kim, Kyung Hwan

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