A novel effect of rebamipide: Generation of [Ca2+](i) oscillations through activation of CCK1 receptors in rat pancreatic acinar cells

Seok Jun Moon, Wooin Ahn, Min Goo Lee, Hyeyoung Kim, Syng Ill Lee, Jeong Taeg Seo, R. Maynard Case, Kyung Hwan Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The protective effect of 2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]-propionic acid (rebamipide) on gastric mucosa is well established. Here we demonstrate that rebamipide acts on pancreatic acinar cells to generate oscillations of intracellular Ca2+ concentration ([Ca2+](i)) through the activation of cholecystokinin subtype 1 (CCK1) receptors. At concentrations higher than 5 μM, rebamipide induced [Ca2+](i) oscillations in individual fura-2-loaded pancreatic acinar cells. The frequency of oscillations increased with increasing concentrations of rebamipide, while the latency between stimulation of cells and initiation of [Ca2+](i) oscillations decreased with increasing concentration. The [Ca2+](i) oscillations evoked by rebamipide were inhibited by the CCK1 receptor antagonist L-364,718 but not by atropine or the CCK2 receptor antagonist L-365,260 indicating that rebamipide is a nonpeptide CCK1 receptor agonist. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalEuropean Journal of Pharmacology
Volume388
Issue number1
DOIs
Publication statusPublished - 2000 Jan 24

All Science Journal Classification (ASJC) codes

  • Pharmacology

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