A novel insertion sequence, ISAba10, inserted into ISAba1 adjacent to the blaOXA-23 gene and disrupting the outer membrane protein gene carO in Acinetobacter baumannii

Yangsoon Lee, Chang Ki Kim, Hyukmin Lee, Seok Hoon Jeong, Dongeun Yong, Kyungwon Lee

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We investigated an outbreak caused by carbapenem-resistant Acinetobacter baumannii carrying the blaOXA-23 gene. A novel insertion sequence (IS), named ISAba10, was found to be inserted into the ISAba1 element preceding the blaOXA-23 gene in a group of isolates showing higher carbapenem MICs. The presence of ISAba10 was associated with increased OXA-23 expression, likely by providing additional promoter sequences. ISAba10 was also inserted into the carO outer membrane protein gene in most of these isolates.

Original languageEnglish
Pages (from-to)361-363
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume55
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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