Abstract
We investigated an outbreak caused by carbapenem-resistant Acinetobacter baumannii carrying the blaOXA-23 gene. A novel insertion sequence (IS), named ISAba10, was found to be inserted into the ISAba1 element preceding the blaOXA-23 gene in a group of isolates showing higher carbapenem MICs. The presence of ISAba10 was associated with increased OXA-23 expression, likely by providing additional promoter sequences. ISAba10 was also inserted into the carO outer membrane protein gene in most of these isolates.
| Original language | English |
|---|---|
| Pages (from-to) | 361-363 |
| Number of pages | 3 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 55 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2011 Jan 1 |
All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
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Cite this
Lee, Y., Kim, C. K., Lee, H., Jeong, S. H., Yong, D., & Lee, K. (2011). A novel insertion sequence, ISAba10, inserted into ISAba1 adjacent to the blaOXA-23 gene and disrupting the outer membrane protein gene carO in Acinetobacter baumannii. Antimicrobial agents and chemotherapy, 55(1), 361-363. https://doi.org/10.1128/AAC.01672-09