TY - JOUR
T1 - A novel insertion sequence, ISAba10, inserted into ISAba1 adjacent to the blaOXA-23 gene and disrupting the outer membrane protein gene carO in Acinetobacter baumannii
AU - Lee, Yangsoon
AU - Kim, Chang Ki
AU - Lee, Hyukmin
AU - Jeong, Seok Hoon
AU - Yong, Dongeun
AU - Lee, Kyungwon
PY - 2011/1
Y1 - 2011/1
N2 - We investigated an outbreak caused by carbapenem-resistant Acinetobacter baumannii carrying the blaOXA-23 gene. A novel insertion sequence (IS), named ISAba10, was found to be inserted into the ISAba1 element preceding the blaOXA-23 gene in a group of isolates showing higher carbapenem MICs. The presence of ISAba10 was associated with increased OXA-23 expression, likely by providing additional promoter sequences. ISAba10 was also inserted into the carO outer membrane protein gene in most of these isolates.
AB - We investigated an outbreak caused by carbapenem-resistant Acinetobacter baumannii carrying the blaOXA-23 gene. A novel insertion sequence (IS), named ISAba10, was found to be inserted into the ISAba1 element preceding the blaOXA-23 gene in a group of isolates showing higher carbapenem MICs. The presence of ISAba10 was associated with increased OXA-23 expression, likely by providing additional promoter sequences. ISAba10 was also inserted into the carO outer membrane protein gene in most of these isolates.
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U2 - 10.1128/AAC.01672-09
DO - 10.1128/AAC.01672-09
M3 - Article
C2 - 20937784
AN - SCOPUS:78650664705
VL - 55
SP - 361
EP - 363
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 1
ER -
