A novel insertion sequence, ISAba10, inserted into ISAba1 adjacent to the blaOXA-23 gene and disrupting the outer membrane protein gene carO in Acinetobacter baumannii

Yangsoon Lee; Chang Ki Kim; Hyukmin Lee; Seok Hoon Jeong; Dongeun Yong; Kyungwon Lee

doi:10.1128/AAC.01672-09

A novel insertion sequence, ISAba10, inserted into ISAba1 adjacent to the bla_OXA-23 gene and disrupting the outer membrane protein gene carO in Acinetobacter baumannii

Yangsoon Lee, Chang Ki Kim, Hyukmin Lee, Seok Hoon Jeong, Dongeun Yong, Kyungwon Lee

Department of Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

We investigated an outbreak caused by carbapenem-resistant Acinetobacter baumannii carrying the bla_OXA-23 gene. A novel insertion sequence (IS), named ISAba10, was found to be inserted into the ISAba1 element preceding the bla_OXA-23 gene in a group of isolates showing higher carbapenem MICs. The presence of ISAba10 was associated with increased OXA-23 expression, likely by providing additional promoter sequences. ISAba10 was also inserted into the carO outer membrane protein gene in most of these isolates.

Original language	English
Pages (from-to)	361-363
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	55
Issue number	1
DOIs	https://doi.org/10.1128/AAC.01672-09
Publication status	Published - 2011 Jan

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "A novel insertion sequence, ISAba10, inserted into ISAba1 adjacent to the blaOXA-23 gene and disrupting the outer membrane protein gene carO in Acinetobacter baumannii",

abstract = "We investigated an outbreak caused by carbapenem-resistant Acinetobacter baumannii carrying the blaOXA-23 gene. A novel insertion sequence (IS), named ISAba10, was found to be inserted into the ISAba1 element preceding the blaOXA-23 gene in a group of isolates showing higher carbapenem MICs. The presence of ISAba10 was associated with increased OXA-23 expression, likely by providing additional promoter sequences. ISAba10 was also inserted into the carO outer membrane protein gene in most of these isolates.",

author = "Yangsoon Lee and Kim, {Chang Ki} and Hyukmin Lee and Jeong, {Seok Hoon} and Dongeun Yong and Kyungwon Lee",

year = "2011",

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doi = "10.1128/AAC.01672-09",

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volume = "55",

pages = "361--363",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

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}

A novel insertion sequence, ISAba10, inserted into ISAba1 adjacent to the bla_OXA-23 gene and disrupting the outer membrane protein gene carO in Acinetobacter baumannii. / Lee, Yangsoon; Kim, Chang Ki; Lee, Hyukmin; Jeong, Seok Hoon ; Yong, Dongeun ; Lee, Kyungwon.

In: Antimicrobial agents and chemotherapy, Vol. 55, No. 1, 01.2011, p. 361-363.

Research output: Contribution to journal › Article › peer-review

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