Abstract
We investigated an outbreak caused by carbapenem-resistant Acinetobacter baumannii carrying the blaOXA-23 gene. A novel insertion sequence (IS), named ISAba10, was found to be inserted into the ISAba1 element preceding the blaOXA-23 gene in a group of isolates showing higher carbapenem MICs. The presence of ISAba10 was associated with increased OXA-23 expression, likely by providing additional promoter sequences. ISAba10 was also inserted into the carO outer membrane protein gene in most of these isolates.
Original language | English |
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Pages (from-to) | 361-363 |
Number of pages | 3 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 55 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2011 Jan |
All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases