A Novel Method of Steroid Delivery to Improve the Efficacy of Intralesional Injection in Keloid Treatment

Mi Yeon Cho; Ahreum Song; Kee Yang Chung; Mi Ryung Roh

doi:10.1097/DSS.0000000000003432

A Novel Method of Steroid Delivery to Improve the Efficacy of Intralesional Injection in Keloid Treatment

Mi Yeon Cho, Ahreum Song, Kee Yang Chung, Mi Ryung Roh

Department of Dermatology

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUNDKeloids are a chronic disease and cause pain, pruritus, and limitation of motion. Intralesional corticosteroid injection is the first-line treatment, but its effects can be limited, even with repeated injections.OBJECTIVETo investigate the efficacy and safety of a tunneling method of corticosteroid injection compared with conventional intralesional injection.MATERIALS AND METHODSA retrospective review was conducted of keloid patients treated with intralesional corticosteroid injection by conventional and tunneling methods.RESULTSA total of 119 cases of keloid were included in the study. Among 78 patients treated with 20 mg/mL triamcinolone, the Investigators' Global Assessment effectiveness score and Observer Scar Assessment Scale (OSAS) score were significantly higher in the tunneling group than the conventional group at 1 month. At 6 months, the tunneling group showed significantly higher effectiveness in the OSAS score than the conventional group. In the tunneling group, the interval between treatments was significantly longer than in the conventional group. The occurrence of side effects was lower in the tunneling method group than in the conventional method group.CONCLUSIONThis study reveals the benefits of the tunneling method over the conventional method for therapeutic effect and side effects in keloid treatment.

Original language	English
Pages (from-to)	631-635
Number of pages	5
Journal	Dermatologic Surgery
Volume	48
Issue number	6
DOIs	https://doi.org/10.1097/DSS.0000000000003432
Publication status	Published - 2022 Jun 1

Bibliographical note

Funding Information:
The patients described in this manuscript have provided written informed consent for publication of their case details. This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MSIT) (No. 2021R1A2C1094638) and a faculty research Grant of Yonsei University College of Medicine (2019-0069).

Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.

All Science Journal Classification (ASJC) codes

Surgery
Dermatology

Access to Document

10.1097/DSS.0000000000003432

Cite this

@article{7bc366de74cd4c208a152bec51235d0d,

title = "A Novel Method of Steroid Delivery to Improve the Efficacy of Intralesional Injection in Keloid Treatment",

abstract = "BACKGROUNDKeloids are a chronic disease and cause pain, pruritus, and limitation of motion. Intralesional corticosteroid injection is the first-line treatment, but its effects can be limited, even with repeated injections.OBJECTIVETo investigate the efficacy and safety of a tunneling method of corticosteroid injection compared with conventional intralesional injection.MATERIALS AND METHODSA retrospective review was conducted of keloid patients treated with intralesional corticosteroid injection by conventional and tunneling methods.RESULTSA total of 119 cases of keloid were included in the study. Among 78 patients treated with 20 mg/mL triamcinolone, the Investigators' Global Assessment effectiveness score and Observer Scar Assessment Scale (OSAS) score were significantly higher in the tunneling group than the conventional group at 1 month. At 6 months, the tunneling group showed significantly higher effectiveness in the OSAS score than the conventional group. In the tunneling group, the interval between treatments was significantly longer than in the conventional group. The occurrence of side effects was lower in the tunneling method group than in the conventional method group.CONCLUSIONThis study reveals the benefits of the tunneling method over the conventional method for therapeutic effect and side effects in keloid treatment.",

author = "Cho, {Mi Yeon} and Ahreum Song and Chung, {Kee Yang} and Roh, {Mi Ryung}",

note = "Funding Information: The patients described in this manuscript have provided written informed consent for publication of their case details. This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MSIT) (No. 2021R1A2C1094638) and a faculty research Grant of Yonsei University College of Medicine (2019-0069). Publisher Copyright: {\textcopyright} 2022 Lippincott Williams and Wilkins. All rights reserved.",

year = "2022",

month = jun,

day = "1",

doi = "10.1097/DSS.0000000000003432",

language = "English",

volume = "48",

pages = "631--635",

journal = "Dermatologic Surgery",

issn = "1076-0512",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - A Novel Method of Steroid Delivery to Improve the Efficacy of Intralesional Injection in Keloid Treatment

AU - Cho, Mi Yeon

AU - Song, Ahreum

AU - Chung, Kee Yang

AU - Roh, Mi Ryung

N1 - Funding Information: The patients described in this manuscript have provided written informed consent for publication of their case details. This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MSIT) (No. 2021R1A2C1094638) and a faculty research Grant of Yonsei University College of Medicine (2019-0069). Publisher Copyright: © 2022 Lippincott Williams and Wilkins. All rights reserved.

PY - 2022/6/1

Y1 - 2022/6/1

N2 - BACKGROUNDKeloids are a chronic disease and cause pain, pruritus, and limitation of motion. Intralesional corticosteroid injection is the first-line treatment, but its effects can be limited, even with repeated injections.OBJECTIVETo investigate the efficacy and safety of a tunneling method of corticosteroid injection compared with conventional intralesional injection.MATERIALS AND METHODSA retrospective review was conducted of keloid patients treated with intralesional corticosteroid injection by conventional and tunneling methods.RESULTSA total of 119 cases of keloid were included in the study. Among 78 patients treated with 20 mg/mL triamcinolone, the Investigators' Global Assessment effectiveness score and Observer Scar Assessment Scale (OSAS) score were significantly higher in the tunneling group than the conventional group at 1 month. At 6 months, the tunneling group showed significantly higher effectiveness in the OSAS score than the conventional group. In the tunneling group, the interval between treatments was significantly longer than in the conventional group. The occurrence of side effects was lower in the tunneling method group than in the conventional method group.CONCLUSIONThis study reveals the benefits of the tunneling method over the conventional method for therapeutic effect and side effects in keloid treatment.

AB - BACKGROUNDKeloids are a chronic disease and cause pain, pruritus, and limitation of motion. Intralesional corticosteroid injection is the first-line treatment, but its effects can be limited, even with repeated injections.OBJECTIVETo investigate the efficacy and safety of a tunneling method of corticosteroid injection compared with conventional intralesional injection.MATERIALS AND METHODSA retrospective review was conducted of keloid patients treated with intralesional corticosteroid injection by conventional and tunneling methods.RESULTSA total of 119 cases of keloid were included in the study. Among 78 patients treated with 20 mg/mL triamcinolone, the Investigators' Global Assessment effectiveness score and Observer Scar Assessment Scale (OSAS) score were significantly higher in the tunneling group than the conventional group at 1 month. At 6 months, the tunneling group showed significantly higher effectiveness in the OSAS score than the conventional group. In the tunneling group, the interval between treatments was significantly longer than in the conventional group. The occurrence of side effects was lower in the tunneling method group than in the conventional method group.CONCLUSIONThis study reveals the benefits of the tunneling method over the conventional method for therapeutic effect and side effects in keloid treatment.

UR - http://www.scopus.com/inward/record.url?scp=85131235591&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85131235591&partnerID=8YFLogxK

U2 - 10.1097/DSS.0000000000003432

DO - 10.1097/DSS.0000000000003432

M3 - Article

C2 - 35653557

AN - SCOPUS:85131235591

SN - 1076-0512

VL - 48

SP - 631

EP - 635

JO - Dermatologic Surgery

JF - Dermatologic Surgery

IS - 6

ER -

A Novel Method of Steroid Delivery to Improve the Efficacy of Intralesional Injection in Keloid Treatment

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this