Abstract
This research presents an multi-stage multi-orifice flow fractionation (MS-MOFF) device designed for achieving high recovery and purity simultaneously. The structure and dimensions of the MS-MOFF were determined by the hy-drodynamic principles to have consistent Reynolds numbers (Re) at each multi-orifice segment. From this device, we achieved improved recovery and maximize purity by collecting and re-separating the non-selected particles. The final recovery increased from 73.2 % to 88.7 % while the purity slightly decreased from 91.4 % to 89.1 %. The MS-MOFF device can be utilized to isolate rare cells from human blood solely by using inertial microfluidic forces.
| Original language | English |
|---|---|
| Title of host publication | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 |
| Pages | 199-201 |
| Number of pages | 3 |
| Publication status | Published - 2010 Dec 1 |
| Event | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands Duration: 2010 Oct 3 → 2010 Oct 7 |
Publication series
| Name | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 |
|---|---|
| Volume | 1 |
Other
| Other | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 |
|---|---|
| Country | Netherlands |
| City | Groningen |
| Period | 10/10/3 → 10/10/7 |
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All Science Journal Classification (ASJC) codes
- Control and Systems Engineering
Cite this
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A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF). / Kwon, Kiho; Sim, Taeseok; Moon, Hui Sung; Lee, Jeong Gun; Park, Jae Chan; Jung, Hyo Il.
14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 2010. p. 199-201 (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 1).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF)
AU - Kwon, Kiho
AU - Sim, Taeseok
AU - Moon, Hui Sung
AU - Lee, Jeong Gun
AU - Park, Jae Chan
AU - Jung, Hyo Il
PY - 2010/12/1
Y1 - 2010/12/1
N2 - This research presents an multi-stage multi-orifice flow fractionation (MS-MOFF) device designed for achieving high recovery and purity simultaneously. The structure and dimensions of the MS-MOFF were determined by the hy-drodynamic principles to have consistent Reynolds numbers (Re) at each multi-orifice segment. From this device, we achieved improved recovery and maximize purity by collecting and re-separating the non-selected particles. The final recovery increased from 73.2 % to 88.7 % while the purity slightly decreased from 91.4 % to 89.1 %. The MS-MOFF device can be utilized to isolate rare cells from human blood solely by using inertial microfluidic forces.
AB - This research presents an multi-stage multi-orifice flow fractionation (MS-MOFF) device designed for achieving high recovery and purity simultaneously. The structure and dimensions of the MS-MOFF were determined by the hy-drodynamic principles to have consistent Reynolds numbers (Re) at each multi-orifice segment. From this device, we achieved improved recovery and maximize purity by collecting and re-separating the non-selected particles. The final recovery increased from 73.2 % to 88.7 % while the purity slightly decreased from 91.4 % to 89.1 %. The MS-MOFF device can be utilized to isolate rare cells from human blood solely by using inertial microfluidic forces.
UR - http://www.scopus.com/inward/record.url?scp=84884296250&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884296250&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84884296250
SN - 9781618390622
T3 - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
SP - 199
EP - 201
BT - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
ER -