A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF)

Kiho Kwon, Taeseok Sim, Hui Sung Moon, Jeong Gun Lee, Jae Chan Park, Hyo Il Jung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

This research presents an multi-stage multi-orifice flow fractionation (MS-MOFF) device designed for achieving high recovery and purity simultaneously. The structure and dimensions of the MS-MOFF were determined by the hy-drodynamic principles to have consistent Reynolds numbers (Re) at each multi-orifice segment. From this device, we achieved improved recovery and maximize purity by collecting and re-separating the non-selected particles. The final recovery increased from 73.2 % to 88.7 % while the purity slightly decreased from 91.4 % to 89.1 %. The MS-MOFF device can be utilized to isolate rare cells from human blood solely by using inertial microfluidic forces.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages199-201
Number of pages3
Publication statusPublished - 2010 Dec 1
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 2010 Oct 32010 Oct 7

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume1

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/10/310/10/7

Fingerprint

Fractionation
Orifices
Recovery
Microfluidics
Reynolds number
Blood

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Cite this

Kwon, K., Sim, T., Moon, H. S., Lee, J. G., Park, J. C., & Jung, H. I. (2010). A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF). In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 199-201). (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 1).
Kwon, Kiho ; Sim, Taeseok ; Moon, Hui Sung ; Lee, Jeong Gun ; Park, Jae Chan ; Jung, Hyo Il. / A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF). 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 2010. pp. 199-201 (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010).
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title = "A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF)",
abstract = "This research presents an multi-stage multi-orifice flow fractionation (MS-MOFF) device designed for achieving high recovery and purity simultaneously. The structure and dimensions of the MS-MOFF were determined by the hy-drodynamic principles to have consistent Reynolds numbers (Re) at each multi-orifice segment. From this device, we achieved improved recovery and maximize purity by collecting and re-separating the non-selected particles. The final recovery increased from 73.2 {\%} to 88.7 {\%} while the purity slightly decreased from 91.4 {\%} to 89.1 {\%}. The MS-MOFF device can be utilized to isolate rare cells from human blood solely by using inertial microfluidic forces.",
author = "Kiho Kwon and Taeseok Sim and Moon, {Hui Sung} and Lee, {Jeong Gun} and Park, {Jae Chan} and Jung, {Hyo Il}",
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Kwon, K, Sim, T, Moon, HS, Lee, JG, Park, JC & Jung, HI 2010, A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF). in 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, vol. 1, pp. 199-201, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, Groningen, Netherlands, 10/10/3.

A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF). / Kwon, Kiho; Sim, Taeseok; Moon, Hui Sung; Lee, Jeong Gun; Park, Jae Chan; Jung, Hyo Il.

14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 2010. p. 199-201 (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - This research presents an multi-stage multi-orifice flow fractionation (MS-MOFF) device designed for achieving high recovery and purity simultaneously. The structure and dimensions of the MS-MOFF were determined by the hy-drodynamic principles to have consistent Reynolds numbers (Re) at each multi-orifice segment. From this device, we achieved improved recovery and maximize purity by collecting and re-separating the non-selected particles. The final recovery increased from 73.2 % to 88.7 % while the purity slightly decreased from 91.4 % to 89.1 %. The MS-MOFF device can be utilized to isolate rare cells from human blood solely by using inertial microfluidic forces.

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Kwon K, Sim T, Moon HS, Lee JG, Park JC, Jung HI. A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF). In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 2010. p. 199-201. (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010).