Abstract
This research presents an multi-stage multi-orifice flow fractionation (MS-MOFF) device designed for achieving high recovery and purity simultaneously. The structure and dimensions of the MS-MOFF were determined by the hy-drodynamic principles to have consistent Reynolds numbers (Re) at each multi-orifice segment. From this device, we achieved improved recovery and maximize purity by collecting and re-separating the non-selected particles. The final recovery increased from 73.2 % to 88.7 % while the purity slightly decreased from 91.4 % to 89.1 %. The MS-MOFF device can be utilized to isolate rare cells from human blood solely by using inertial microfluidic forces.
| Original language | English |
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| Title of host publication | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 |
| Pages | 199-201 |
| Number of pages | 3 |
| Publication status | Published - 2010 Dec 1 |
| Event | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands Duration: 2010 Oct 3 → 2010 Oct 7 |
Publication series
| Name | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 |
|---|---|
| Volume | 1 |
Other
| Other | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 |
|---|---|
| Country | Netherlands |
| City | Groningen |
| Period | 10/10/3 → 10/10/7 |
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All Science Journal Classification (ASJC) codes
- Control and Systems Engineering
Cite this
Kwon, K., Sim, T., Moon, H. S., Lee, J. G., Park, J. C., & Jung, H. I. (2010). A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF). In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 199-201). (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 1).