A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF)

Kiho Kwon; Taeseok Sim; Hui Sung Moon; Jeong Gun Lee; Jae Chan Park; Hyo Il Jung

A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF)

Kiho Kwon, Taeseok Sim, Hui Sung Moon, Jeong Gun Lee, Jae Chan Park, Hyo Il Jung

Department of Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

This research presents an multi-stage multi-orifice flow fractionation (MS-MOFF) device designed for achieving high recovery and purity simultaneously. The structure and dimensions of the MS-MOFF were determined by the hy-drodynamic principles to have consistent Reynolds numbers (Re) at each multi-orifice segment. From this device, we achieved improved recovery and maximize purity by collecting and re-separating the non-selected particles. The final recovery increased from 73.2 % to 88.7 % while the purity slightly decreased from 91.4 % to 89.1 %. The MS-MOFF device can be utilized to isolate rare cells from human blood solely by using inertial microfluidic forces.

Original language	English
Title of host publication	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages	199-201
Number of pages	3
Publication status	Published - 2010
Event	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands Duration: 2010 Oct 3 → 2010 Oct 7

Publication series

Name	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume	1

Other

Other	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Country	Netherlands
City	Groningen
Period	10/10/3 → 10/10/7

All Science Journal Classification (ASJC) codes

Control and Systems Engineering

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Kwon, K., Sim, T., Moon, H. S., Lee, J. G., Park, J. C., & Jung, H. I. (2010). A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF). In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 199-201). (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 1).

Kwon, Kiho ; Sim, Taeseok ; Moon, Hui Sung ; Lee, Jeong Gun ; Park, Jae Chan ; Jung, Hyo Il. / A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF). 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 2010. pp. 199-201 (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010).

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title = "A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF)",

abstract = "This research presents an multi-stage multi-orifice flow fractionation (MS-MOFF) device designed for achieving high recovery and purity simultaneously. The structure and dimensions of the MS-MOFF were determined by the hy-drodynamic principles to have consistent Reynolds numbers (Re) at each multi-orifice segment. From this device, we achieved improved recovery and maximize purity by collecting and re-separating the non-selected particles. The final recovery increased from 73.2 % to 88.7 % while the purity slightly decreased from 91.4 % to 89.1 %. The MS-MOFF device can be utilized to isolate rare cells from human blood solely by using inertial microfluidic forces.",

author = "Kiho Kwon and Taeseok Sim and Moon, {Hui Sung} and Lee, {Jeong Gun} and Park, {Jae Chan} and Jung, {Hyo Il}",

note = "Copyright: Copyright 2013 Elsevier B.V., All rights reserved.; 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 ; Conference date: 03-10-2010 Through 07-10-2010",

year = "2010",

language = "English",

isbn = "9781618390622",

series = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",

pages = "199--201",

booktitle = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",

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Kwon, K, Sim, T, Moon, HS, Lee, JG, Park, JC & Jung, HI 2010, A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF). in 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, vol. 1, pp. 199-201, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, Groningen, Netherlands, 10/10/3.

A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF). / Kwon, Kiho; Sim, Taeseok; Moon, Hui Sung; Lee, Jeong Gun; Park, Jae Chan; Jung, Hyo Il.

14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 2010. p. 199-201 (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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T1 - A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF)

AU - Kwon, Kiho

AU - Sim, Taeseok

AU - Moon, Hui Sung

AU - Lee, Jeong Gun

AU - Park, Jae Chan

AU - Jung, Hyo Il

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N2 - This research presents an multi-stage multi-orifice flow fractionation (MS-MOFF) device designed for achieving high recovery and purity simultaneously. The structure and dimensions of the MS-MOFF were determined by the hy-drodynamic principles to have consistent Reynolds numbers (Re) at each multi-orifice segment. From this device, we achieved improved recovery and maximize purity by collecting and re-separating the non-selected particles. The final recovery increased from 73.2 % to 88.7 % while the purity slightly decreased from 91.4 % to 89.1 %. The MS-MOFF device can be utilized to isolate rare cells from human blood solely by using inertial microfluidic forces.

AB - This research presents an multi-stage multi-orifice flow fractionation (MS-MOFF) device designed for achieving high recovery and purity simultaneously. The structure and dimensions of the MS-MOFF were determined by the hy-drodynamic principles to have consistent Reynolds numbers (Re) at each multi-orifice segment. From this device, we achieved improved recovery and maximize purity by collecting and re-separating the non-selected particles. The final recovery increased from 73.2 % to 88.7 % while the purity slightly decreased from 91.4 % to 89.1 %. The MS-MOFF device can be utilized to isolate rare cells from human blood solely by using inertial microfluidic forces.

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BT - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010

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Y2 - 3 October 2010 through 7 October 2010

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Kwon K, Sim T, Moon HS, Lee JG, Park JC, Jung HI. A novel particle separation method using multi-stage multi-orifice flow fractionation (MS-MOFF). In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 2010. p. 199-201. (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010).