A novel peptide, nicotinyl–isoleucine–valine–histidine (Na–IVH), promotes antioxidant gene expression and wound healing in HaCaT cells

Dong Hwee Son, Dong Joo Yang, Ji Su Sun, Seul Ki Kim, Namju Kang, Jung Yun Kang, Yun Hee Choi, Jeong Hun Lee, Sang Hyun Moh, Dong Min Shin, Ki Woo Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Nicotinamide (NA), a water-soluble Vitamin B3, has been shown to exert cellular-protective effects against reactive oxygen species (ROS). In order to improve the cellular-protective effects of NA, we synthesized a novel compound, nicotinyl–isoleucine–valine–histidine (NA–IVH), by combining NA with jellyfish peptides’ IVH. In the present study, we examined the cellular-protective effects of the novel synthetic nicotinyl-peptide, NA–IVH. We found that NA–IVH enhances the radical scavenging activity with a robust increase of the nuclear factor (erythroid-derived 2)-like factor (Nrf2) expression in human HaCaT keratinocytes. In addition, NA–IVH protected the cells from hydrogen peroxide (H2O2)-induced cell death. Interestingly, NA–IVH exhibited an improved wound-healing effect in a high glucose condition, possibly through the regulation of reactive oxygen species (ROS). Collectively, our results imply that a novel nicotinyl-peptide, NA–IVH, has a wound-healing effect in a hyperglycemic condition, possibly by modulating excessive ROS.

Original languageEnglish
Article number262
JournalMarine Drugs
Volume16
Issue number8
DOIs
Publication statusPublished - 2018 Aug 1

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Niacinamide
Wound Healing
Antioxidants
Gene Expression
Reactive Oxygen Species
Peptides
Keratinocytes
Hydrogen Peroxide
Cell Death
Glucose
Water

All Science Journal Classification (ASJC) codes

  • Drug Discovery

Cite this

Son, Dong Hwee ; Yang, Dong Joo ; Sun, Ji Su ; Kim, Seul Ki ; Kang, Namju ; Kang, Jung Yun ; Choi, Yun Hee ; Lee, Jeong Hun ; Moh, Sang Hyun ; Shin, Dong Min ; Kim, Ki Woo. / A novel peptide, nicotinyl–isoleucine–valine–histidine (Na–IVH), promotes antioxidant gene expression and wound healing in HaCaT cells. In: Marine Drugs. 2018 ; Vol. 16, No. 8.
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abstract = "Nicotinamide (NA), a water-soluble Vitamin B3, has been shown to exert cellular-protective effects against reactive oxygen species (ROS). In order to improve the cellular-protective effects of NA, we synthesized a novel compound, nicotinyl–isoleucine–valine–histidine (NA–IVH), by combining NA with jellyfish peptides’ IVH. In the present study, we examined the cellular-protective effects of the novel synthetic nicotinyl-peptide, NA–IVH. We found that NA–IVH enhances the radical scavenging activity with a robust increase of the nuclear factor (erythroid-derived 2)-like factor (Nrf2) expression in human HaCaT keratinocytes. In addition, NA–IVH protected the cells from hydrogen peroxide (H2O2)-induced cell death. Interestingly, NA–IVH exhibited an improved wound-healing effect in a high glucose condition, possibly through the regulation of reactive oxygen species (ROS). Collectively, our results imply that a novel nicotinyl-peptide, NA–IVH, has a wound-healing effect in a hyperglycemic condition, possibly by modulating excessive ROS.",
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A novel peptide, nicotinyl–isoleucine–valine–histidine (Na–IVH), promotes antioxidant gene expression and wound healing in HaCaT cells. / Son, Dong Hwee; Yang, Dong Joo; Sun, Ji Su; Kim, Seul Ki; Kang, Namju; Kang, Jung Yun; Choi, Yun Hee; Lee, Jeong Hun; Moh, Sang Hyun; Shin, Dong Min; Kim, Ki Woo.

In: Marine Drugs, Vol. 16, No. 8, 262, 01.08.2018.

Research output: Contribution to journalArticle

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AU - Son, Dong Hwee

AU - Yang, Dong Joo

AU - Sun, Ji Su

AU - Kim, Seul Ki

AU - Kang, Namju

AU - Kang, Jung Yun

AU - Choi, Yun Hee

AU - Lee, Jeong Hun

AU - Moh, Sang Hyun

AU - Shin, Dong Min

AU - Kim, Ki Woo

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N2 - Nicotinamide (NA), a water-soluble Vitamin B3, has been shown to exert cellular-protective effects against reactive oxygen species (ROS). In order to improve the cellular-protective effects of NA, we synthesized a novel compound, nicotinyl–isoleucine–valine–histidine (NA–IVH), by combining NA with jellyfish peptides’ IVH. In the present study, we examined the cellular-protective effects of the novel synthetic nicotinyl-peptide, NA–IVH. We found that NA–IVH enhances the radical scavenging activity with a robust increase of the nuclear factor (erythroid-derived 2)-like factor (Nrf2) expression in human HaCaT keratinocytes. In addition, NA–IVH protected the cells from hydrogen peroxide (H2O2)-induced cell death. Interestingly, NA–IVH exhibited an improved wound-healing effect in a high glucose condition, possibly through the regulation of reactive oxygen species (ROS). Collectively, our results imply that a novel nicotinyl-peptide, NA–IVH, has a wound-healing effect in a hyperglycemic condition, possibly by modulating excessive ROS.

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