A novel peptide, nicotinyl–isoleucine–valine–histidine (Na–IVH), promotes antioxidant gene expression and wound healing in HaCaT cells

Dong Hwee Son, Dong Joo Yang, Ji Su Sun, Seul Ki Kim, Namju Kang, Jung Yun Kang, Yun Hee Choi, Jeong Hun Lee, Sang Hyun Moh, Dong Min Shin, Ki Woo Kim

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Nicotinamide (NA), a water-soluble Vitamin B3, has been shown to exert cellular-protective effects against reactive oxygen species (ROS). In order to improve the cellular-protective effects of NA, we synthesized a novel compound, nicotinyl–isoleucine–valine–histidine (NA–IVH), by combining NA with jellyfish peptides’ IVH. In the present study, we examined the cellular-protective effects of the novel synthetic nicotinyl-peptide, NA–IVH. We found that NA–IVH enhances the radical scavenging activity with a robust increase of the nuclear factor (erythroid-derived 2)-like factor (Nrf2) expression in human HaCaT keratinocytes. In addition, NA–IVH protected the cells from hydrogen peroxide (H2O2)-induced cell death. Interestingly, NA–IVH exhibited an improved wound-healing effect in a high glucose condition, possibly through the regulation of reactive oxygen species (ROS). Collectively, our results imply that a novel nicotinyl-peptide, NA–IVH, has a wound-healing effect in a hyperglycemic condition, possibly by modulating excessive ROS.

Original languageEnglish
Article number262
JournalMarine Drugs
Volume16
Issue number8
DOIs
Publication statusPublished - 2018 Aug 1

Bibliographical note

Funding Information:
Funding: This research was funded by the National Research Foundation, grant numbers [2016R1C1B3012748 and 2016R1A5A2008630], and the Korea Health Industry Development Institute, grant number [HI17C0745] for K.W.K. The research also was supported by National Research Foundation, grant numbers [2016R1A5A2008630] for D.M.S.

Funding Information:
Acknowledgments: We would like to thank Ann W. Kinyua (Yonsei University) for the critical reading of this manuscript. This study was partly supported by the 2015 Ildong Foodis Research Grant from Korean Society for the Study of Obesity.

Funding Information:
This research was funded by the National Research Foundation, grant numbers [2016R1C1B3012748 and 2016R1A5A2008630], and the Korea Health Industry Development Institute, grant number [HI17C0745] for K.W.K. The research also was supported by National Research Foundation, grant numbers [2016R1A5A2008630] for D.M.S.

Publisher Copyright:
© 2018 by the authors.

All Science Journal Classification (ASJC) codes

  • Drug Discovery

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