A novel pH-sensitive membrane from chitosan - TEOS IPN; preparation and its drug permeation characteristics

Seong Bae Park, Jin Oh You, Ham Yong Park, Seungjoo Haam, Woo Sik Kim

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

A novel organic-inorganic composite membrane was prepared, using tetra ethyl ortho silicate (TEOS) as an inorganic material and chitosan as an organic compound. Equilibrium and oscillatory swelling studies were conducted to investigate swelling behaviors of the membrane according to the pH of the swelling medium. Drug permeation experiments were also performed in phosphate buffer solution of the pH of 2.5 and 7.5, respectively. Lidocaine·HCl, sodium salicylate and 4-acetamidophenol were selected as model drugs to examine the effect of ionic property of drug on the permeation behavior. The effects of membrane composition and the external pH on the swelling and the drug permeation behavior of IPN membrane could be summarized as follows; chitosan incorporated into TEOS IPN swelled at pH 2.5 while shrunk at pH 7.5. This swelling behavior was completely reversible and the membrane responded rapidly to the change in environmental pH condition. According to swelling behavior, an increase in pH from 2.5 to 7.5 yielded an increase in the rate of drug permeation because of the shrinking of the incorporated chitosan in TEOS IPN, while decrease in pH resulted in low permeation rate. The optimal TEOS-chitosan ratio for maximum pH-sensitivity existed and drug permeation was influenced not only with the external pH but also with the ionic interactions between the drug and membrane. (C) 2001 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)323-330
Number of pages8
JournalBiomaterials
Volume22
Issue number4
DOIs
Publication statusPublished - 2001 Feb 15

Fingerprint

Silicates
Drug Compounding
Chitosan
Permeation
Swelling
Membranes
Pharmaceutical Preparations
Sodium Salicylate
Composite membranes
Organic compounds
Acetaminophen
Phosphates
Sodium
Buffers
Drug Interactions
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Park, Seong Bae ; You, Jin Oh ; Park, Ham Yong ; Haam, Seungjoo ; Kim, Woo Sik. / A novel pH-sensitive membrane from chitosan - TEOS IPN; preparation and its drug permeation characteristics. In: Biomaterials. 2001 ; Vol. 22, No. 4. pp. 323-330.
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A novel pH-sensitive membrane from chitosan - TEOS IPN; preparation and its drug permeation characteristics. / Park, Seong Bae; You, Jin Oh; Park, Ham Yong; Haam, Seungjoo; Kim, Woo Sik.

In: Biomaterials, Vol. 22, No. 4, 15.02.2001, p. 323-330.

Research output: Contribution to journalArticle

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