A novel tripeptide derived from Chlorella vulgaris regulates skin homeostasis through antioxidant activity

Jae Gap Han, Atul Kulkarni, Jin Young Jeon, Bo Ra Kim, Mi Young Song, Hee Yong Jeong, Dong Joo Yang, Seung Hun You, Ki Woo Kim, Sang Hyun Moh, Jae Kwan Hwang

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Abstract

The marine green alga Chlorella vulgaris produces secondary metabolites including functional nutrients and associated bioactive peptides for protection against harmful environmental stress, suggesting that C. vulgaris extracts may be beneficial for skin homeostasis via protection against UV radiation and reactive oxygen species (ROS). In this study, we identified a cysteine-alanine-serine (CAS) tripeptide from C. vulgaris using LC-MS/MS and NMR and investigated whether the CAS tripeptide can protect skin cells from ROS species. CAS tripeptide was added to a human skin cell line and this treatment resulted in the upregulation of antioxidant genes. In addition, we identified significant induction of procollagen C endopeptidase enhancer (PCOLCE) protein production, which is related to skin firming, due to exposure to CAS tripeptide. The combined results suggest that the microalgae-derived CAS tripeptide might be a valuable biomaterial for modulation of skin homeostasis through antioxidant activity.

Original languageEnglish
Pages (from-to)2476-2480
Number of pages5
JournalScience of Advanced Materials
Volume7
Issue number11
DOIs
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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    Han, J. G., Kulkarni, A., Jeon, J. Y., Kim, B. R., Song, M. Y., Jeong, H. Y., Yang, D. J., You, S. H., Kim, K. W., Moh, S. H., & Hwang, J. K. (2015). A novel tripeptide derived from Chlorella vulgaris regulates skin homeostasis through antioxidant activity. Science of Advanced Materials, 7(11), 2476-2480. https://doi.org/10.1166/sam.2015.2434