A novel tripeptide derived from Chlorella vulgaris regulates skin homeostasis through antioxidant activity

Jae Gap Han, Atul Kulkarni, Jin Young Jeon, Bo Ra Kim, Mi Young Song, Hee Yong Jeong, Dong Joo Yang, Seung Hun You, Kiwoo Kim, Sang Hyun Moh, Jae-Kwan Hwang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The marine green alga Chlorella vulgaris produces secondary metabolites including functional nutrients and associated bioactive peptides for protection against harmful environmental stress, suggesting that C. vulgaris extracts may be beneficial for skin homeostasis via protection against UV radiation and reactive oxygen species (ROS). In this study, we identified a cysteine-alanine-serine (CAS) tripeptide from C. vulgaris using LC-MS/MS and NMR and investigated whether the CAS tripeptide can protect skin cells from ROS species. CAS tripeptide was added to a human skin cell line and this treatment resulted in the upregulation of antioxidant genes. In addition, we identified significant induction of procollagen C endopeptidase enhancer (PCOLCE) protein production, which is related to skin firming, due to exposure to CAS tripeptide. The combined results suggest that the microalgae-derived CAS tripeptide might be a valuable biomaterial for modulation of skin homeostasis through antioxidant activity.

Original languageEnglish
Pages (from-to)2476-2480
Number of pages5
JournalScience of Advanced Materials
Volume7
Issue number11
DOIs
Publication statusPublished - 2015 Jan 1

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Antioxidants
Alanine
Serine
Cysteine
Skin
Reactive Oxygen Species
Bone Morphogenetic Protein 1
Oxygen
Biocompatible Materials
Algae
Metabolites
Biomaterials
Ultraviolet radiation
Peptides
Nutrients
Genes
Cells
Nuclear magnetic resonance
Modulation
Proteins

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Han, Jae Gap ; Kulkarni, Atul ; Jeon, Jin Young ; Kim, Bo Ra ; Song, Mi Young ; Jeong, Hee Yong ; Yang, Dong Joo ; You, Seung Hun ; Kim, Kiwoo ; Moh, Sang Hyun ; Hwang, Jae-Kwan. / A novel tripeptide derived from Chlorella vulgaris regulates skin homeostasis through antioxidant activity. In: Science of Advanced Materials. 2015 ; Vol. 7, No. 11. pp. 2476-2480.
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abstract = "The marine green alga Chlorella vulgaris produces secondary metabolites including functional nutrients and associated bioactive peptides for protection against harmful environmental stress, suggesting that C. vulgaris extracts may be beneficial for skin homeostasis via protection against UV radiation and reactive oxygen species (ROS). In this study, we identified a cysteine-alanine-serine (CAS) tripeptide from C. vulgaris using LC-MS/MS and NMR and investigated whether the CAS tripeptide can protect skin cells from ROS species. CAS tripeptide was added to a human skin cell line and this treatment resulted in the upregulation of antioxidant genes. In addition, we identified significant induction of procollagen C endopeptidase enhancer (PCOLCE) protein production, which is related to skin firming, due to exposure to CAS tripeptide. The combined results suggest that the microalgae-derived CAS tripeptide might be a valuable biomaterial for modulation of skin homeostasis through antioxidant activity.",
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Han, JG, Kulkarni, A, Jeon, JY, Kim, BR, Song, MY, Jeong, HY, Yang, DJ, You, SH, Kim, K, Moh, SH & Hwang, J-K 2015, 'A novel tripeptide derived from Chlorella vulgaris regulates skin homeostasis through antioxidant activity', Science of Advanced Materials, vol. 7, no. 11, pp. 2476-2480. https://doi.org/10.1166/sam.2015.2434

A novel tripeptide derived from Chlorella vulgaris regulates skin homeostasis through antioxidant activity. / Han, Jae Gap; Kulkarni, Atul; Jeon, Jin Young; Kim, Bo Ra; Song, Mi Young; Jeong, Hee Yong; Yang, Dong Joo; You, Seung Hun; Kim, Kiwoo; Moh, Sang Hyun; Hwang, Jae-Kwan.

In: Science of Advanced Materials, Vol. 7, No. 11, 01.01.2015, p. 2476-2480.

Research output: Contribution to journalArticle

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AU - Han, Jae Gap

AU - Kulkarni, Atul

AU - Jeon, Jin Young

AU - Kim, Bo Ra

AU - Song, Mi Young

AU - Jeong, Hee Yong

AU - Yang, Dong Joo

AU - You, Seung Hun

AU - Kim, Kiwoo

AU - Moh, Sang Hyun

AU - Hwang, Jae-Kwan

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