Marine green alga Chlorella vulgaris produces secondary metabolitesincluding functional nutrients and associated bioactive peptides to protect harmful and environmental stresses. These evidences suggest that Chlorella vulgaris extracts have several beneficial effects on skin homeostasis such as protection against UV radiation and reactive oxygen species (ROS). In this study, we newly identified cysteine-alanine-serine (CAS) tripeptide from Chlorella vulgaris using LC-MS/MS and NMR. We investigated whether the identified CAS has beneficial effect of the protection from ROS species on skin cells. CAS was treated on the human skin cell line and this resulted in increment of anti-oxidant genes. In addition, we identified the significant induction of procollagen C endopeptidase enhancer (PCOLCE) which is related to skin firming by CAS. Combined all together, these results suggest that microalgae-derived CAS tripeptidemight be a valuable biomaterial in modulating skin homeostasis through its antioxidant function.
All Science Journal Classification (ASJC) codes
- Materials Science(all)