A novel tripeptide derived from Chlorella vulgaris regulates skin homeostasis through its antioxidant function

Jae Gap Han, Atul Kulkarni, Jin Young Jeon, Bo Ra Kim, Mi Young Song, Hee Yong Jeong, Dong Joo Yang, Seung Hun You, Ki Woo Kim, Sang Hyun Moh, Jae Kwan Hwang

Research output: Contribution to journalArticle

Abstract

Marine green alga Chlorella vulgaris produces secondary metabolitesincluding functional nutrients and associated bioactive peptides to protect harmful and environmental stresses. These evidences suggest that Chlorella vulgaris extracts have several beneficial effects on skin homeostasis such as protection against UV radiation and reactive oxygen species (ROS). In this study, we newly identified cysteine-alanine-serine (CAS) tripeptide from Chlorella vulgaris using LC-MS/MS and NMR. We investigated whether the identified CAS has beneficial effect of the protection from ROS species on skin cells. CAS was treated on the human skin cell line and this resulted in increment of anti-oxidant genes. In addition, we identified the significant induction of procollagen C endopeptidase enhancer (PCOLCE) which is related to skin firming by CAS. Combined all together, these results suggest that microalgae-derived CAS tripeptidemight be a valuable biomaterial in modulating skin homeostasis through its antioxidant function.

Original languageEnglish
Pages (from-to)2545-2550
Number of pages6
JournalScience of Advanced Materials
Volume7
Issue number12
DOIs
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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    Han, J. G., Kulkarni, A., Jeon, J. Y., Kim, B. R., Song, M. Y., Jeong, H. Y., Yang, D. J., You, S. H., Kim, K. W., Moh, S. H., & Hwang, J. K. (2015). A novel tripeptide derived from Chlorella vulgaris regulates skin homeostasis through its antioxidant function. Science of Advanced Materials, 7(12), 2545-2550. https://doi.org/10.1166/sam.2015.2440