A Novel Ultrafine Needle (UN) for Innocuous and Efficient Subcutaneous Insulin Delivery

Cheng Guo Li, Yonghao Ma, Inyoung Huh, Shayan Fakhraei Lahiji, Sang Guk Lee, Hyungil Jung

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Subcutaneous (SC) insulin injection has been demonstrated to be the most effective method for treatment of diabetes mellitus but is conventionally performed by hypodermic needles, leading to poor management of diabetes because of the pain, needle phobia, and tissue trauma. Identification of a viable, safe, and pain-free alternative method has been a longstanding challenge in modern health care. Here, the thermoplastic droplet stretching technique is developed to create an ultrahigh-aspect-ratio needle mold with simple microstructure control. The optimized ultrafine needle (UN) with 4 mm length, minimized 120 µm outer diameter, and 15° sharp bevel angle is formed via electroplating of a metallic layer on the surface of a needle mold with forcing sharp tip. This novel UN enables minimally invasive 4 mm skin insertion to deliver insulin in the targeted SC layer. The similar relative areas under the curves of insulin concentration within UN and 31G needle in vivo insulin administration indicate that UN can ensure stable insulin absorption for secure blood glucose management. Additionally, the proposed fabrication method may facilitate industrialization and commercialization of the UN, holding great promise for replacement of hypodermic needles and for improvement of quality of life among patients with diabetes.

Original languageEnglish
Article number1603228
JournalAdvanced Functional Materials
Volume27
Issue number2
DOIs
Publication statusPublished - 2017 Jan 12

Fingerprint

insulin
Insulin
needles
Needles
delivery
Medical problems
pain
phobias
Ultrafine
diabetes mellitus
commercialization
electroplating
Electroplating
Health care
glucose
Thermoplastics
Stretching
health
blood
Glucose

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Condensed Matter Physics
  • Electrochemistry

Cite this

Li, Cheng Guo ; Ma, Yonghao ; Huh, Inyoung ; Lahiji, Shayan Fakhraei ; Lee, Sang Guk ; Jung, Hyungil. / A Novel Ultrafine Needle (UN) for Innocuous and Efficient Subcutaneous Insulin Delivery. In: Advanced Functional Materials. 2017 ; Vol. 27, No. 2.
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A Novel Ultrafine Needle (UN) for Innocuous and Efficient Subcutaneous Insulin Delivery. / Li, Cheng Guo; Ma, Yonghao; Huh, Inyoung; Lahiji, Shayan Fakhraei; Lee, Sang Guk; Jung, Hyungil.

In: Advanced Functional Materials, Vol. 27, No. 2, 1603228, 12.01.2017.

Research output: Contribution to journalArticle

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