A numerical study on the elastic modulus of volume and area dilation for a deformable cell in a microchannel

Ji Young Moon, Roger I. Tanner, Joon Sang Lee

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

A red blood cell (RBC) in a microfluidic channel is highly interesting forscientists in various fields of research on biological systems. This system hasbeen studied extensively by empirical, analytical, and numerical methods.Nonetheless, research of predicting the behavior of an RBC in a microchannelis still an interesting area. The complications arise from deformation of anRBC and interactions among the surrounding fluid, wall, and RBCs. In thisstudy, a pressure-driven RBC in a microchannel was simulated with a threedimensionallattice Boltzmann method of an immersed boundary. First, theeffect of boundary thickness on the interaction between the wall and cell wasanalyzed by measuring the time of passage through the narrow channel.Second, the effect of volume conservation stiffness was studied. Finally, theeffect of global area stiffness was analyzed.

Original languageEnglish
Article number044110
JournalBiomicrofluidics
Volume10
Issue number4
DOIs
Publication statusPublished - 2016 Jul 1

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Fluid Flow and Transfer Processes
  • Colloid and Surface Chemistry

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