A one-pot total synthesis of crambin

Duhee Bang, Stephen B.H. Kent

Research output: Contribution to journalArticle

242 Citations (Scopus)


Making up for lost time: The one-pot synthesis of crambin (see structure) with only a single final purification step gave the target protein of exceptional purity in only two days with an overall yield of ≈40%. Three unprotected peptide segments were linked by native chemical ligation, and the polypeptide chain assumed its 3D structure without intermediate purification steps.

Original languageEnglish
Pages (from-to)2534-2538
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number19
Publication statusPublished - 2004 May 3

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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