A patient-specific model of virtual ablation for atrial fibrillation

Soon Sung Kwon, Yong H.yun Yun, Seung Bae Hong, Hui Nam Pak, Eun B.o. Shim

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to propose a patient-specific model of atrial fibrillation (AF) and apply it to virtual radiofrequency ablation (RFA). We obtained patient-specific geometries of the left atrium (LA) from CT data and constructed three-dimensional (3D) simulation models. A bidomain Courtemanche model was used to simulate the 3D electric waves on the LA surface, and an S1-S2 protocol was applied to induce AF in the model. To identify scar areas in the models, we converted clinically measured voltage data on the LA surface to the scar maps of the simulation model. Then, after initiation of AF, we applied the virtual ablation scheme to the model and investigated whether the AF was terminated by the scheme. The computed results of AF and ablation were similar to those of clinical observation, providing a clinically important simulation method for preclinical virtual trials of AF treatment.

Fingerprint

Ablation
Atrial Fibrillation
Heart Atria
Cicatrix
Electromagnetic waves
Observation
Geometry
Electric potential

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

@article{2513fb38c9ba4eac84d4e98de6912ed2,
title = "A patient-specific model of virtual ablation for atrial fibrillation",
abstract = "The purpose of this study was to propose a patient-specific model of atrial fibrillation (AF) and apply it to virtual radiofrequency ablation (RFA). We obtained patient-specific geometries of the left atrium (LA) from CT data and constructed three-dimensional (3D) simulation models. A bidomain Courtemanche model was used to simulate the 3D electric waves on the LA surface, and an S1-S2 protocol was applied to induce AF in the model. To identify scar areas in the models, we converted clinically measured voltage data on the LA surface to the scar maps of the simulation model. Then, after initiation of AF, we applied the virtual ablation scheme to the model and investigated whether the AF was terminated by the scheme. The computed results of AF and ablation were similar to those of clinical observation, providing a clinically important simulation method for preclinical virtual trials of AF treatment.",
author = "Kwon, {Soon Sung} and Yun, {Yong H.yun} and Hong, {Seung Bae} and Pak, {Hui Nam} and Shim, {Eun B.o.}",
year = "2013",
month = "1",
day = "1",
doi = "10.1109/EMBC.2013.6609802",
language = "English",
volume = "2013",
pages = "1522--1525",
journal = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
issn = "1557-170X",
publisher = "Institute of Electrical and Electronics Engineers Inc.",

}

TY - JOUR

T1 - A patient-specific model of virtual ablation for atrial fibrillation

AU - Kwon, Soon Sung

AU - Yun, Yong H.yun

AU - Hong, Seung Bae

AU - Pak, Hui Nam

AU - Shim, Eun B.o.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - The purpose of this study was to propose a patient-specific model of atrial fibrillation (AF) and apply it to virtual radiofrequency ablation (RFA). We obtained patient-specific geometries of the left atrium (LA) from CT data and constructed three-dimensional (3D) simulation models. A bidomain Courtemanche model was used to simulate the 3D electric waves on the LA surface, and an S1-S2 protocol was applied to induce AF in the model. To identify scar areas in the models, we converted clinically measured voltage data on the LA surface to the scar maps of the simulation model. Then, after initiation of AF, we applied the virtual ablation scheme to the model and investigated whether the AF was terminated by the scheme. The computed results of AF and ablation were similar to those of clinical observation, providing a clinically important simulation method for preclinical virtual trials of AF treatment.

AB - The purpose of this study was to propose a patient-specific model of atrial fibrillation (AF) and apply it to virtual radiofrequency ablation (RFA). We obtained patient-specific geometries of the left atrium (LA) from CT data and constructed three-dimensional (3D) simulation models. A bidomain Courtemanche model was used to simulate the 3D electric waves on the LA surface, and an S1-S2 protocol was applied to induce AF in the model. To identify scar areas in the models, we converted clinically measured voltage data on the LA surface to the scar maps of the simulation model. Then, after initiation of AF, we applied the virtual ablation scheme to the model and investigated whether the AF was terminated by the scheme. The computed results of AF and ablation were similar to those of clinical observation, providing a clinically important simulation method for preclinical virtual trials of AF treatment.

UR - http://www.scopus.com/inward/record.url?scp=84938878305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938878305&partnerID=8YFLogxK

U2 - 10.1109/EMBC.2013.6609802

DO - 10.1109/EMBC.2013.6609802

M3 - Article

C2 - 24109989

VL - 2013

SP - 1522

EP - 1525

JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

SN - 1557-170X

ER -