A phase II study of preoperative mFOLFOX6 with short-course radiotherapy in patients with locally advanced rectal cancer and liver-only metastasis

Kyung Hwan Kim, Sang Joon Shin, Min Soo Cho, Joong Bae Ahn, Minkyu Jung, Tae Il Kim, Young Suk Park, Hoguen Kim, Nam Kyu Kim, Woong Sub Koom

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Background and purpose To evaluate the efficacy and safety of upfront mFOLFOX6 followed by short-course radiotherapy (SCRT) and surgery in patients with locally advanced rectal cancer and liver-only metastases. Materials and methods This single-arm phase II study involved 32 patients. mFOLFOX6 was administered for four cycles followed by SCRT and another four cycles of mFOLFOX6. Surgery was performed 4-6 weeks after the last chemotherapy cycle. The primary endpoint was complete (R0) resection rate. Secondary endpoints were response rate, progression-free survival (PFS), overall survival (OS), and complication rates. Results Surgical resection of the rectum and liver was performed in 25 patients (78%) and R0 resection was achieved in 20 patients (63%). Local tumor downstaging was observed in 54% of patients. Median OS and PFS were 38 and 9 months, respectively. One patient discontinued treatment due to toxicity and no treatment-related deaths occurred. Patients who progressed after 4 cycles of mFOLFOX6 were less likely to receive resection. Conclusions This regimen was safe and effective in inducing local tumor response and achieving R0 resection in this patient population.

Original languageEnglish
Pages (from-to)369-374
Number of pages6
JournalRadiotherapy and Oncology
Volume118
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

Bibliographical note

Funding Information:
Source of funding: This study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare , Republic of Korea ( 1420270 ) and a faculty research grant of Yonsei University College of Medicine for 2011 ( 6-2011-0138 ).

Publisher Copyright:
© 2015 Elsevier Ireland Ltd.

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

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