Background and purpose To evaluate the efficacy and safety of upfront mFOLFOX6 followed by short-course radiotherapy (SCRT) and surgery in patients with locally advanced rectal cancer and liver-only metastases. Materials and methods This single-arm phase II study involved 32 patients. mFOLFOX6 was administered for four cycles followed by SCRT and another four cycles of mFOLFOX6. Surgery was performed 4-6 weeks after the last chemotherapy cycle. The primary endpoint was complete (R0) resection rate. Secondary endpoints were response rate, progression-free survival (PFS), overall survival (OS), and complication rates. Results Surgical resection of the rectum and liver was performed in 25 patients (78%) and R0 resection was achieved in 20 patients (63%). Local tumor downstaging was observed in 54% of patients. Median OS and PFS were 38 and 9 months, respectively. One patient discontinued treatment due to toxicity and no treatment-related deaths occurred. Patients who progressed after 4 cycles of mFOLFOX6 were less likely to receive resection. Conclusions This regimen was safe and effective in inducing local tumor response and achieving R0 resection in this patient population.
|Number of pages||6|
|Journal||Radiotherapy and Oncology|
|Publication status||Published - 2016 Feb 1|
Bibliographical noteFunding Information:
Source of funding: This study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare , Republic of Korea ( 1420270 ) and a faculty research grant of Yonsei University College of Medicine for 2011 ( 6-2011-0138 ).
© 2015 Elsevier Ireland Ltd.
All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging