A Phenol-Amine Superglue Inspired by Insect Sclerotization Process

Younseon Wang; Eun Je Jeon; Jeehee Lee; Honggu Hwang; Seung Woo Cho; Haeshin Lee

doi:10.1002/adma.202002118

A Phenol-Amine Superglue Inspired by Insect Sclerotization Process

Younseon Wang, Eun Je Jeon, Jeehee Lee, Honggu Hwang, Seung Woo Cho, Haeshin Lee

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Exoskeletons of insects formed by sclerotization processes exhibit superstrong properties in moduli. Here, it is demonstrated that mimicking the sclerotization process using phenol and polyamine molecules unexpectedly results in a 100% ecofriendly, biocompatible waterborne superglue. Oxygen presented in air and dissolved in water acts as an initiator producing phenolic radical/quinone for superglue curing. Despite synthesis-free uses of water, phenol, and polyamine, its adhesion strength is comparable to commercial epoxy glue showing >6 MPa in lap shear strength. The phenol-amine superglue bonds to various substrates including ceramics, woods, fabrics, plastics, metals, and importantly biological tissues. Due to strong adhesion, the superglue effectively seals wounds within a few seconds, and, due to its waterborne nature, no harmful respiratory effect is observed because of any release of volatile organic compounds. The easy, cost-effective preparation of the phenol-amine superglue can revolutionize varieties of industrial, biomedical, daily life processes.

Original language	English
Article number	2002118
Journal	Advanced Materials
Volume	32
Issue number	43
DOIs	https://doi.org/10.1002/adma.202002118
Publication status	Published - 2020 Oct 1

Bibliographical note

Funding Information:
Y.W. and E.J.J. contributed equally to this work. This research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (MSIT): Development program for convergence R&D over traditional culture and current technology (2016M3C1B5906485, H.L.), Center for Multiscale Chiral Architectures (2018R1A5A1025208, H.L.), and Bio & Medical Technology Development Program (2018M3A9H1021382, S.‐W.C). This work was also supported by the KIST Institutional Program (Project 2V07080, H.L.), the Institute for Basic Science (IBS‐R026‐D1, S.‐W.C), and Brain Korea 21(BK21) PLUS program. E.J.J. is fellowship awardee by BK21 PLUS program. This research was partially supported by the Graduate School of YONSEI University Research Scholarship Grants in 2020. All animal experiment protocols were approved by the Institutional Animal Care and Use Committee (IACUC) of the Yonsei University (approval number: IACUC‐A‐201707‐292‐01).

Funding Information:
Y.W. and E.J.J. contributed equally to this work. This research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (MSIT): Development program for convergence R&D over traditional culture and current technology (2016M3C1B5906485, H.L.), Center for Multiscale Chiral Architectures (2018R1A5A1025208, H.L.), and Bio & Medical Technology Development Program (2018M3A9H1021382, S.-W.C). This work was also supported by the KIST Institutional Program (Project 2V07080, H.L.), the Institute for Basic Science (IBS-R026-D1, S.-W.C), and Brain Korea 21(BK21) PLUS program. E.J.J. is fellowship awardee by BK21 PLUS program. This research was partially supported by the Graduate School of YONSEI University Research Scholarship Grants in 2020. All animal experiment protocols were approved by the Institutional Animal Care and Use Committee (IACUC) of the Yonsei University (approval number: IACUC-A-201707-292-01).

Publisher Copyright:
© 2020 Wiley-VCH GmbH

All Science Journal Classification (ASJC) codes

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.202002118

Cite this

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title = "A Phenol-Amine Superglue Inspired by Insect Sclerotization Process",

abstract = "Exoskeletons of insects formed by sclerotization processes exhibit superstrong properties in moduli. Here, it is demonstrated that mimicking the sclerotization process using phenol and polyamine molecules unexpectedly results in a 100% ecofriendly, biocompatible waterborne superglue. Oxygen presented in air and dissolved in water acts as an initiator producing phenolic radical/quinone for superglue curing. Despite synthesis-free uses of water, phenol, and polyamine, its adhesion strength is comparable to commercial epoxy glue showing >6 MPa in lap shear strength. The phenol-amine superglue bonds to various substrates including ceramics, woods, fabrics, plastics, metals, and importantly biological tissues. Due to strong adhesion, the superglue effectively seals wounds within a few seconds, and, due to its waterborne nature, no harmful respiratory effect is observed because of any release of volatile organic compounds. The easy, cost-effective preparation of the phenol-amine superglue can revolutionize varieties of industrial, biomedical, daily life processes.",

author = "Younseon Wang and Jeon, {Eun Je} and Jeehee Lee and Honggu Hwang and Cho, {Seung Woo} and Haeshin Lee",

note = "Funding Information: Y.W. and E.J.J. contributed equally to this work. This research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (MSIT): Development program for convergence R&D over traditional culture and current technology (2016M3C1B5906485, H.L.), Center for Multiscale Chiral Architectures (2018R1A5A1025208, H.L.), and Bio & Medical Technology Development Program (2018M3A9H1021382, S.‐W.C). This work was also supported by the KIST Institutional Program (Project 2V07080, H.L.), the Institute for Basic Science (IBS‐R026‐D1, S.‐W.C), and Brain Korea 21(BK21) PLUS program. E.J.J. is fellowship awardee by BK21 PLUS program. This research was partially supported by the Graduate School of YONSEI University Research Scholarship Grants in 2020. All animal experiment protocols were approved by the Institutional Animal Care and Use Committee (IACUC) of the Yonsei University (approval number: IACUC‐A‐201707‐292‐01). Funding Information: Y.W. and E.J.J. contributed equally to this work. This research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (MSIT): Development program for convergence R&D over traditional culture and current technology (2016M3C1B5906485, H.L.), Center for Multiscale Chiral Architectures (2018R1A5A1025208, H.L.), and Bio & Medical Technology Development Program (2018M3A9H1021382, S.-W.C). This work was also supported by the KIST Institutional Program (Project 2V07080, H.L.), the Institute for Basic Science (IBS-R026-D1, S.-W.C), and Brain Korea 21(BK21) PLUS program. E.J.J. is fellowship awardee by BK21 PLUS program. This research was partially supported by the Graduate School of YONSEI University Research Scholarship Grants in 2020. All animal experiment protocols were approved by the Institutional Animal Care and Use Committee (IACUC) of the Yonsei University (approval number: IACUC-A-201707-292-01). Publisher Copyright: {\textcopyright} 2020 Wiley-VCH GmbH",

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AU - Cho, Seung Woo

AU - Lee, Haeshin

N1 - Funding Information: Y.W. and E.J.J. contributed equally to this work. This research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (MSIT): Development program for convergence R&D over traditional culture and current technology (2016M3C1B5906485, H.L.), Center for Multiscale Chiral Architectures (2018R1A5A1025208, H.L.), and Bio & Medical Technology Development Program (2018M3A9H1021382, S.‐W.C). This work was also supported by the KIST Institutional Program (Project 2V07080, H.L.), the Institute for Basic Science (IBS‐R026‐D1, S.‐W.C), and Brain Korea 21(BK21) PLUS program. E.J.J. is fellowship awardee by BK21 PLUS program. This research was partially supported by the Graduate School of YONSEI University Research Scholarship Grants in 2020. All animal experiment protocols were approved by the Institutional Animal Care and Use Committee (IACUC) of the Yonsei University (approval number: IACUC‐A‐201707‐292‐01). Funding Information: Y.W. and E.J.J. contributed equally to this work. This research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (MSIT): Development program for convergence R&D over traditional culture and current technology (2016M3C1B5906485, H.L.), Center for Multiscale Chiral Architectures (2018R1A5A1025208, H.L.), and Bio & Medical Technology Development Program (2018M3A9H1021382, S.-W.C). This work was also supported by the KIST Institutional Program (Project 2V07080, H.L.), the Institute for Basic Science (IBS-R026-D1, S.-W.C), and Brain Korea 21(BK21) PLUS program. E.J.J. is fellowship awardee by BK21 PLUS program. This research was partially supported by the Graduate School of YONSEI University Research Scholarship Grants in 2020. All animal experiment protocols were approved by the Institutional Animal Care and Use Committee (IACUC) of the Yonsei University (approval number: IACUC-A-201707-292-01). Publisher Copyright: © 2020 Wiley-VCH GmbH

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N2 - Exoskeletons of insects formed by sclerotization processes exhibit superstrong properties in moduli. Here, it is demonstrated that mimicking the sclerotization process using phenol and polyamine molecules unexpectedly results in a 100% ecofriendly, biocompatible waterborne superglue. Oxygen presented in air and dissolved in water acts as an initiator producing phenolic radical/quinone for superglue curing. Despite synthesis-free uses of water, phenol, and polyamine, its adhesion strength is comparable to commercial epoxy glue showing >6 MPa in lap shear strength. The phenol-amine superglue bonds to various substrates including ceramics, woods, fabrics, plastics, metals, and importantly biological tissues. Due to strong adhesion, the superglue effectively seals wounds within a few seconds, and, due to its waterborne nature, no harmful respiratory effect is observed because of any release of volatile organic compounds. The easy, cost-effective preparation of the phenol-amine superglue can revolutionize varieties of industrial, biomedical, daily life processes.

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A Phenol-Amine Superglue Inspired by Insect Sclerotization Process

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