A phenylpropanoid glycoside as a calcineurin inhibitor isolated from Magnolia obovata Thunb

Won Jeong Lee, Jae Sun Moon, Sung In Kim, Yong-Sun Bahn, Hanna Lee, Tae Hoon Kang, Heung Mook Shin, Sung Uk Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

To identify plant-derived cell signaling inhibitors with antifungal properties, a twocomponent screening system using both wild-type Cryptococcus neoformans and a calcineurin mutant was employed owing to their counter-regulatory actions on the Hog1 mitogenactivated protein kinase and calcineurin pathways. Of the 2,000 plant extracts evaluated, a single bioactive compound from M. obovata Thunb. was found to act specifically on the calcineurin pathway of C. neoformans. This compound was identified as magnoloside A, and had potent antifungal activities against various Cryptococcus strains with minimum inhibitory concentration values ranging from 1.0 to 4.0 μg/ml.

Original languageEnglish
Pages (from-to)1429-1432
Number of pages4
JournalJournal of microbiology and biotechnology
Volume25
Issue number9
DOIs
Publication statusPublished - 2015 Jul 13

Fingerprint

Magnolia
Calcineurin
Glycosides
Cryptococcus neoformans
Cryptococcus
Plant Extracts
Plant Cells
Microbial Sensitivity Tests
Protein Kinases
Calcineurin Inhibitors

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Lee, Won Jeong ; Moon, Jae Sun ; Kim, Sung In ; Bahn, Yong-Sun ; Lee, Hanna ; Kang, Tae Hoon ; Shin, Heung Mook ; Kim, Sung Uk. / A phenylpropanoid glycoside as a calcineurin inhibitor isolated from Magnolia obovata Thunb. In: Journal of microbiology and biotechnology. 2015 ; Vol. 25, No. 9. pp. 1429-1432.
@article{11c83a46acb947f2a80b4624d34e77c4,
title = "A phenylpropanoid glycoside as a calcineurin inhibitor isolated from Magnolia obovata Thunb",
abstract = "To identify plant-derived cell signaling inhibitors with antifungal properties, a twocomponent screening system using both wild-type Cryptococcus neoformans and a calcineurin mutant was employed owing to their counter-regulatory actions on the Hog1 mitogenactivated protein kinase and calcineurin pathways. Of the 2,000 plant extracts evaluated, a single bioactive compound from M. obovata Thunb. was found to act specifically on the calcineurin pathway of C. neoformans. This compound was identified as magnoloside A, and had potent antifungal activities against various Cryptococcus strains with minimum inhibitory concentration values ranging from 1.0 to 4.0 μg/ml.",
author = "Lee, {Won Jeong} and Moon, {Jae Sun} and Kim, {Sung In} and Yong-Sun Bahn and Hanna Lee and Kang, {Tae Hoon} and Shin, {Heung Mook} and Kim, {Sung Uk}",
year = "2015",
month = "7",
day = "13",
doi = "10.4014/jmb.1506.06031",
language = "English",
volume = "25",
pages = "1429--1432",
journal = "Journal of Microbiology and Biotechnology",
issn = "1017-7825",
publisher = "Korean Society for Microbiolog and Biotechnology",
number = "9",

}

A phenylpropanoid glycoside as a calcineurin inhibitor isolated from Magnolia obovata Thunb. / Lee, Won Jeong; Moon, Jae Sun; Kim, Sung In; Bahn, Yong-Sun; Lee, Hanna; Kang, Tae Hoon; Shin, Heung Mook; Kim, Sung Uk.

In: Journal of microbiology and biotechnology, Vol. 25, No. 9, 13.07.2015, p. 1429-1432.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A phenylpropanoid glycoside as a calcineurin inhibitor isolated from Magnolia obovata Thunb

AU - Lee, Won Jeong

AU - Moon, Jae Sun

AU - Kim, Sung In

AU - Bahn, Yong-Sun

AU - Lee, Hanna

AU - Kang, Tae Hoon

AU - Shin, Heung Mook

AU - Kim, Sung Uk

PY - 2015/7/13

Y1 - 2015/7/13

N2 - To identify plant-derived cell signaling inhibitors with antifungal properties, a twocomponent screening system using both wild-type Cryptococcus neoformans and a calcineurin mutant was employed owing to their counter-regulatory actions on the Hog1 mitogenactivated protein kinase and calcineurin pathways. Of the 2,000 plant extracts evaluated, a single bioactive compound from M. obovata Thunb. was found to act specifically on the calcineurin pathway of C. neoformans. This compound was identified as magnoloside A, and had potent antifungal activities against various Cryptococcus strains with minimum inhibitory concentration values ranging from 1.0 to 4.0 μg/ml.

AB - To identify plant-derived cell signaling inhibitors with antifungal properties, a twocomponent screening system using both wild-type Cryptococcus neoformans and a calcineurin mutant was employed owing to their counter-regulatory actions on the Hog1 mitogenactivated protein kinase and calcineurin pathways. Of the 2,000 plant extracts evaluated, a single bioactive compound from M. obovata Thunb. was found to act specifically on the calcineurin pathway of C. neoformans. This compound was identified as magnoloside A, and had potent antifungal activities against various Cryptococcus strains with minimum inhibitory concentration values ranging from 1.0 to 4.0 μg/ml.

UR - http://www.scopus.com/inward/record.url?scp=84941894039&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941894039&partnerID=8YFLogxK

U2 - 10.4014/jmb.1506.06031

DO - 10.4014/jmb.1506.06031

M3 - Article

VL - 25

SP - 1429

EP - 1432

JO - Journal of Microbiology and Biotechnology

JF - Journal of Microbiology and Biotechnology

SN - 1017-7825

IS - 9

ER -