A planar split-ring resonator-based microwave biosensor for label-free detection of biomolecules

Hee Jo Lee, Jung Hyun Lee, Hui Sung Moon, Ik Soon Jang, Jong Soon Choi, Jong Gwan Yook, Hyo Il Jung

Research output: Contribution to journalArticlepeer-review

177 Citations (Scopus)


In this study, a planar split-ring resonator (SRR)-based RF biosensor was developed for label-free detection of biomolecules such as the prostate cancer marker, prostate specific antigen (PSA), and cortisol stress hormone. The biosensor has a resonance-assisted transducer and is excited by a time-varying magnetic field component of a local high-impedance microstrip line. The resulting device exhibits an intrinsic S 21 resonance with a quality-factor (or Q-factor) of 50. For the biomolecular interaction, anti-PSA and anti-cortisol were immobilized on the gold surface of the resonator by a protein-G mediated bioconjugation process and corresponding frequency shifts of Δf1p=302MHz (for anti-PSA) and Δf1c=203MHz (for anti-cortisol) were observed. The additional frequency shift of each PSA and cortisol antigen with a 100 pg/ml concentration was about 5 ± 1.5 MHz and 3 ± 1 MHz, respectively. From the experimental results, we confirmed that our device is very effective RF biosensor with a limit of detection (LOD) of 100 pg/ml and has sufficiently feasibility as a label-free biosensing scheme.

Original languageEnglish
Pages (from-to)26-31
Number of pages6
JournalSensors and Actuators, B: Chemical
Publication statusPublished - 2012 Jul 5

Bibliographical note

Funding Information:
This study was supported by grants from the National R&D Program for Cancer Control, Ministry of Health & Welfare (No.1120290), the National Research Foundation of Korea (NRF) (No.2011-0016731) and the Korean Basic Science Institute (No. T3278B).

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry


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