A polymorphism of the renin gene rs6682082 is associated with essential hypertension risk and blood pressure levels in Korean women

Jongkeun Park, Kijun Song, Yangsoo Jang, Sungjoo Kim Yoon

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: The aim of the present study was to investigate associations between the renin gene (REN) and the risk of essential hypertension and blood pressure (BP) levels in Koreans. Materials and Methods: To outline the functional role of a single nucleotide polymorphism in the transcription of the REN gene, we conducted a case-control study of 1975 individuals: 646 hypertension (HT) patients and 1329 ethnically and age-matched normotensive subjects. Results: Logistic regression analysis indicated that the genotypes AA/AG were strongly associated with risk of HT (odds ratio, 1.493; 95% confidence interval, 1.069‒2.086, p=0.018) in female subjects. The genotypes AA/AG also showed significant association with higher blood pressure levels, both systolic and diastolic, in postmenopausal HT women (p=0.003 and p=0.017, respectively). Analysis of the promoter containing rs6682082 revealed a 2.4±0.01-fold higher activity in the A variant promoter than the G variant promoter, suggesting that rs6682082 is itself a functional variant. Conclusion: We suggest that the A allele of rs6682082 is a positive genetic marker for predisposition to essential hypertension and high BP in Korean women and may be mediated through the transcriptional activation of REN.

Original languageEnglish
Pages (from-to)227-234
Number of pages8
JournalYonsei medical journal
Volume56
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

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Renin
Blood Pressure
Hypertension
Genes
Genotype
Genetic Predisposition to Disease
Genetic Markers
Transcriptional Activation
Single Nucleotide Polymorphism
Case-Control Studies
Logistic Models
Alleles
Odds Ratio
Regression Analysis
Essential Hypertension
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "Purpose: The aim of the present study was to investigate associations between the renin gene (REN) and the risk of essential hypertension and blood pressure (BP) levels in Koreans. Materials and Methods: To outline the functional role of a single nucleotide polymorphism in the transcription of the REN gene, we conducted a case-control study of 1975 individuals: 646 hypertension (HT) patients and 1329 ethnically and age-matched normotensive subjects. Results: Logistic regression analysis indicated that the genotypes AA/AG were strongly associated with risk of HT (odds ratio, 1.493; 95{\%} confidence interval, 1.069‒2.086, p=0.018) in female subjects. The genotypes AA/AG also showed significant association with higher blood pressure levels, both systolic and diastolic, in postmenopausal HT women (p=0.003 and p=0.017, respectively). Analysis of the promoter containing rs6682082 revealed a 2.4±0.01-fold higher activity in the A variant promoter than the G variant promoter, suggesting that rs6682082 is itself a functional variant. Conclusion: We suggest that the A allele of rs6682082 is a positive genetic marker for predisposition to essential hypertension and high BP in Korean women and may be mediated through the transcriptional activation of REN.",
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A polymorphism of the renin gene rs6682082 is associated with essential hypertension risk and blood pressure levels in Korean women. / Park, Jongkeun; Song, Kijun; Jang, Yangsoo; Yoon, Sungjoo Kim.

In: Yonsei medical journal, Vol. 56, No. 1, 01.01.2015, p. 227-234.

Research output: Contribution to journalArticle

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