A potential therapeutic effect of saikosaponin C as a novel dual-target anti-Alzheimer agent

Tae Ho Lee, Sungha Park, Mi Hyeon You, Ji Hong Lim, Sang Hyun Min, Byeong Mo Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a chronic neurodegenerative disease and the risk of developing it increases with advancing age. In this study, we investigated the protective effects of saikosaponin C (SSc), one of the main bioactive components produced by the traditional Chinese herb, radix bupleuri, the root of Bupleurum falcatum, against AD in various neuronal models. Interestingly, we found that SSc has dual effects on AD by targeting amyloid beta (Aβ) and tau, two key proteins in AD. SSc significantly suppressed the release of both Aβ peptides 1-40 and 1-42 into cell culture supernatants, though it does not affect BACE1 activity and expression. SSc also inhibited abnormal tau phosphorylation at multiple AD-related residues. Moreover, SSc seems to have beneficial effects on cellular tau function; it accelerated nerve growth factor-mediated neurite outgrowth and increased the assembly of microtubules. In addition, SSc increased synaptic marker proteins such as synaptophysin and PSD-95. Considering its various biological activities, our results suggest that SSc might be a novel therapeutic tool for treating human AD and other neurodegenerative diseases.

Original languageEnglish
Pages (from-to)1232-1245
Number of pages14
JournalJournal of Neurochemistry
Volume136
Issue number6
DOIs
Publication statusPublished - 2016 Mar 1

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

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