A practical and efficient method for the preparation of sulfonamides utilizing Cl3CCN/PPh3

Oraphin Chantarasriwong, Doo Ok Jang, Warinthorn Chavasiri

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Cl3CCN in combination with PPh3 proved to be a highly reactive reagent for the conversion of sulfonic acids to the corresponding sulfonyl chlorides in refluxing CH2Cl2. Upon reaction with amines, the corresponding sulfonamides were obtained in good to excellent yields.

Original languageEnglish
Pages (from-to)7489-7492
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number42
DOIs
Publication statusPublished - 2006 Oct 16

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Sulfonic Acids
Sulfonamides
Amines
sulfonyl chloride

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Chantarasriwong, Oraphin ; Jang, Doo Ok ; Chavasiri, Warinthorn. / A practical and efficient method for the preparation of sulfonamides utilizing Cl3CCN/PPh3. In: Tetrahedron Letters. 2006 ; Vol. 47, No. 42. pp. 7489-7492.
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A practical and efficient method for the preparation of sulfonamides utilizing Cl3CCN/PPh3. / Chantarasriwong, Oraphin; Jang, Doo Ok; Chavasiri, Warinthorn.

In: Tetrahedron Letters, Vol. 47, No. 42, 16.10.2006, p. 7489-7492.

Research output: Contribution to journalArticle

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