A practical and efficient method for the preparation of sulfonamides utilizing Cl3CCN/PPh3

Oraphin Chantarasriwong, Doo Ok Jang, Warinthorn Chavasiri

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27 Citations (Scopus)


Cl3CCN in combination with PPh3 proved to be a highly reactive reagent for the conversion of sulfonic acids to the corresponding sulfonyl chlorides in refluxing CH2Cl2. Upon reaction with amines, the corresponding sulfonamides were obtained in good to excellent yields.

Original languageEnglish
Pages (from-to)7489-7492
Number of pages4
JournalTetrahedron Letters
Issue number42
Publication statusPublished - 2006 Oct 16


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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