A procedure for identifying master regulators in conjunction with network screening and inference

Shigeru Saito, Xinrong Zhou, Taejeong Bae, Sunghoon Kim, Katsuhisa Horimoto

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

We developed a procedure for indentifying transcriptional master regulators (MRs) related to special biological phenomena, such as diseases, in conjunction with network screening and inference. Network screening is a system for detecting activated transcriptional regulatory networks under particular conditions, based on the estimation of the graph structure consistency with the measured data. Since the network screening utilizes the known transcriptional factor (TF)-gene relationships as the experimental evidence for the molecular relationships, its performance depends on the ensemble of known TF networks used for its analysis. To compensate for its restrictions, a network inference method, the path consistency algorithm, is concomitantly utilized to identify MRs. The performance is illustrated by means of the known MRs in brain tumors that were computationally inferred and experimentally verified. As a result, the present procedure worked well for identifying MRs, in comparison to the previous computational selection for experimental verification.

Original languageEnglish
Title of host publicationProceedings - 2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010
Pages296-301
Number of pages6
DOIs
Publication statusPublished - 2010 Dec 1
Event2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010 - Hong Kong, China
Duration: 2010 Dec 182010 Dec 21

Publication series

NameProceedings - 2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010

Other

Other2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010
CountryChina
CityHong Kong
Period10/12/1810/12/21

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Health Informatics

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  • Cite this

    Saito, S., Zhou, X., Bae, T., Kim, S., & Horimoto, K. (2010). A procedure for identifying master regulators in conjunction with network screening and inference. In Proceedings - 2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010 (pp. 296-301). [5706580] (Proceedings - 2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010). https://doi.org/10.1109/BIBM.2010.5706580