A prospective observation of psychological distress in patients with anaphylaxis

Youngsoo Lee, Hyoung Yoon Chang, Sang Ha Kim, Min Suk Yang, Young Il Koh, Hye Ryun Kang, Jeong Hee Choi, Cheol Woo Kim, Hye Kyung Park, Joo Hee Kim, Young Hee Nam, Tae Bum Kim, Gyu Young Hur, Jae Woo Jung, Kyung Hee Park, Mi Ae Kim, Jiwoong Kim, Jiwon Yoon, Young Min Ye

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Purpose: Anaphylaxis is an immediate allergic reaction characterized by potentially life-threatening, severe, systemic manifestations. While studies have evaluated links between serious illness and posttraumatic stress disorder (PTSD), few have investigated PTSD after anaphylaxis in adults. We sought to investigate the psychosocial burden of recent anaphylaxis in Korean adults. Methods: A total of 203 (mean age of 44 years, 120 females) patients with anaphylaxis were recruited from 15 university hospitals in Korea. Questionnaires, including the Impact of Event Scale-Revised-Korean version (IES-R-K), the Korean version of the Beck Anxiety Inventory (K-BAI), and the Korean version of the Beck Depression Inventory (K-BDI), were administered. Demographic characteristics, causes and clinical features of anaphylaxis, and serum inflammatory markers, including tryptase, platelet-activating factor, interleukin-6, tumor necrosis factor-α, and C-reactive protein, were evaluated. Results: PTSD (IES-R-K ≥ 25) was noted in 84 (41.4%) patients with anaphylaxis. Of them, 56.0% had severe PTSD (IES-R-K ≥ 40). Additionally, 23.2% and 28.1% of the patients had anxiety (K-BAI ≥ 22) and depression (K-BDI ≥ 17), respectively. IES-R-K was significantly correlated with both K-BAI (r = 0.609, P < 0.0001) and K-BDI (r = 0.550, P < 0.0001). Among the inflammatory mediators, tryptase levels were lower in patients exhibiting PTSD; meanwhile, platelet-activating factor levels were lower in patients exhibiting anxiety and depression while recovering from anaphylaxis. In multivariate analysis, K-BAI and K-BDI were identified as major predictive variables of PTSD in patients with anaphylaxis. Conclusions: In patients with anaphylaxis, we found a remarkably high prevalence of PTSD and associated psychological distresses, including anxiety and depression. Physicians ought to be aware of the potential for psychological distress in anaphylactic patients and to consider psychological evaluation.

Original languageEnglish
Pages (from-to)496-506
Number of pages11
JournalAllergy, Asthma and Immunology Research
Issue number3
Publication statusPublished - 2020 May

Bibliographical note

Funding Information:
This research was supported by the Korean Academy of Asthma, Allergy and Clinical Immunology and partly by a National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2018R1A2B6006199).

Publisher Copyright:
© 2020 The Korean Academy of Asthma.

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'A prospective observation of psychological distress in patients with anaphylaxis'. Together they form a unique fingerprint.

Cite this