A prospective randomized study of gemcitabine with doxifluridine versus paclitaxel with doxifluridine in concurrent chemoradiotherapy for locally advanced pancreatic cancer

Hye Won Chung, Seung Min Bang, Seung Woo Park, Jae Bock Chung, Jin Kyung Kang, Ju Won Kim, Jin Sil Seong, Woo Jung Lee, Si Young Song

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Abstract

The objective of this study was to compare the efficacy and toxicity of gemcitabine-based concurrent chemoradiotherapy (CCRT) with paclitaxel-based CCRT in patients with locally advanced pancreatic cancer. A total of 48 patients who had received no prior therapy were enrolled. The patients were treated with 4500 cGy radiation in 25 fractions over 5 weeks concomitant with gemcitabine 1000 mg/m 2/week/intravenously (IV) and doxifluridine 600 mg/m 2/day/by mouth (PO), or paclitaxel 50 mg/m 2/week/IV and doxifluridine 600 mg/m 2/day/PO. After a 4-week rest, the responses were evaluated and maintenance therapies (operation or chemotherapy) (gemcitabine 1000 mg/m 2/week/IV and doxifluridine 600 mg/m 2/day/PO) were conducted. The median survival was 12 months in the gemcitabine group vs. 14 months in the paclitaxel group. The response rate was 13.6% vs. 25%, and the median time to progression was 12 months vs. 12.5 months, respectively. The positive rate of the clinical benefit response was 59.1% vs. 41.7%, respectively. Toxicities were acceptable in both groups. In this trial, we demonstrated that the gemcitabine-based CCRT and the paclitaxel-based CCRT in combination of doxifluridine are clearly acceptable treatment strategy, and appear more effective than the 5 fluorouracil-based CCRT for locally advanced pancreatic cancer with comparable tolerability. Furthermore, the paclitaxel-based CCRT showed similar efficacy and toxicities to the gemcitabine-based treatment when it was combined with 5-fluorouracil.

Original languageEnglish
Pages (from-to)1494-1501
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Volume60
Issue number5
DOIs
Publication statusPublished - 2004 Dec 1

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All Science Journal Classification (ASJC) codes

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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