A prospective study of epicardial adipose tissue and incident metabolic syndrome: The ARIRANG study

Ji Hyun Lee, Jang Young Kim, Kyung Min Kim, Jun Won Lee, Young Jin Youn, Min Soo Ahn, Byung Su Yoo, Seung Hwan Lee, Junghan Yoon, Kyung Hoon Choe, Song Vogue Ahn, Sang Baek Koh, Jong Ku Park, Sung Gyun Ahn

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Increased epicardial adipose tissue (EAT) may be closely associated with the development of metabolic abnormalities. We investigated whether EAT predicts the incident metabolic syndrome in a community-based, middle-aged population. The study subjects were comprised of 354 adults (134 men and 220 women) aged 40 to 70 yr without metabolic syndrome. Baseline EAT thickness, measured by echocardiography, was compared between subjects who developed new-onset metabolic syndrome at follow-up survey and those who did not. After an average of 2.2 yr of follow-up, 32 men (23.9%) and 37 women (16.8%) developed metabolic syndrome. Median EAT thickness at baseline was significantly higher in male subjects who developed metabolic syndrome than those who did not (1.52 mm vs 2.37 mm, P<0.001). The highest quartile of EAT thickness (≥2.55 mm) was associated with increased risk of progression to metabolic syndrome (Odds ratio [OR], 3.09; 95% confidence interval [CI], 1.11-8.66) after adjustment for age, smoking, alcohol intake, regular exercise, total energy intake, high sensitive C-reactive protein and homeostasis model assessment of insulin resistance in men. A significant association of EAT with incident metabolic syndrome was not seen in women (OR, 1.25; 95% CI, 0.54-2.90). In conclusion, increased EAT thickness is an independent predictor for incident metabolic syndrome in men.

Original languageEnglish
Pages (from-to)1762-1767
Number of pages6
JournalJournal of Korean medical science
Volume28
Issue number12
DOIs
Publication statusPublished - 2013 Jan 1

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Adipose Tissue
Prospective Studies
Odds Ratio
Confidence Intervals
Energy Intake
C-Reactive Protein
Echocardiography
Insulin Resistance
Homeostasis
Smoking
Alcohols
Exercise
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "A prospective study of epicardial adipose tissue and incident metabolic syndrome: The ARIRANG study",
abstract = "Increased epicardial adipose tissue (EAT) may be closely associated with the development of metabolic abnormalities. We investigated whether EAT predicts the incident metabolic syndrome in a community-based, middle-aged population. The study subjects were comprised of 354 adults (134 men and 220 women) aged 40 to 70 yr without metabolic syndrome. Baseline EAT thickness, measured by echocardiography, was compared between subjects who developed new-onset metabolic syndrome at follow-up survey and those who did not. After an average of 2.2 yr of follow-up, 32 men (23.9{\%}) and 37 women (16.8{\%}) developed metabolic syndrome. Median EAT thickness at baseline was significantly higher in male subjects who developed metabolic syndrome than those who did not (1.52 mm vs 2.37 mm, P<0.001). The highest quartile of EAT thickness (≥2.55 mm) was associated with increased risk of progression to metabolic syndrome (Odds ratio [OR], 3.09; 95{\%} confidence interval [CI], 1.11-8.66) after adjustment for age, smoking, alcohol intake, regular exercise, total energy intake, high sensitive C-reactive protein and homeostasis model assessment of insulin resistance in men. A significant association of EAT with incident metabolic syndrome was not seen in women (OR, 1.25; 95{\%} CI, 0.54-2.90). In conclusion, increased EAT thickness is an independent predictor for incident metabolic syndrome in men.",
author = "Lee, {Ji Hyun} and Kim, {Jang Young} and Kim, {Kyung Min} and Lee, {Jun Won} and Youn, {Young Jin} and Ahn, {Min Soo} and Yoo, {Byung Su} and Lee, {Seung Hwan} and Junghan Yoon and Choe, {Kyung Hoon} and Ahn, {Song Vogue} and Koh, {Sang Baek} and Park, {Jong Ku} and Ahn, {Sung Gyun}",
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A prospective study of epicardial adipose tissue and incident metabolic syndrome : The ARIRANG study. / Lee, Ji Hyun; Kim, Jang Young; Kim, Kyung Min; Lee, Jun Won; Youn, Young Jin; Ahn, Min Soo; Yoo, Byung Su; Lee, Seung Hwan; Yoon, Junghan; Choe, Kyung Hoon; Ahn, Song Vogue; Koh, Sang Baek; Park, Jong Ku; Ahn, Sung Gyun.

In: Journal of Korean medical science, Vol. 28, No. 12, 01.01.2013, p. 1762-1767.

Research output: Contribution to journalArticle

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T1 - A prospective study of epicardial adipose tissue and incident metabolic syndrome

T2 - The ARIRANG study

AU - Lee, Ji Hyun

AU - Kim, Jang Young

AU - Kim, Kyung Min

AU - Lee, Jun Won

AU - Youn, Young Jin

AU - Ahn, Min Soo

AU - Yoo, Byung Su

AU - Lee, Seung Hwan

AU - Yoon, Junghan

AU - Choe, Kyung Hoon

AU - Ahn, Song Vogue

AU - Koh, Sang Baek

AU - Park, Jong Ku

AU - Ahn, Sung Gyun

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N2 - Increased epicardial adipose tissue (EAT) may be closely associated with the development of metabolic abnormalities. We investigated whether EAT predicts the incident metabolic syndrome in a community-based, middle-aged population. The study subjects were comprised of 354 adults (134 men and 220 women) aged 40 to 70 yr without metabolic syndrome. Baseline EAT thickness, measured by echocardiography, was compared between subjects who developed new-onset metabolic syndrome at follow-up survey and those who did not. After an average of 2.2 yr of follow-up, 32 men (23.9%) and 37 women (16.8%) developed metabolic syndrome. Median EAT thickness at baseline was significantly higher in male subjects who developed metabolic syndrome than those who did not (1.52 mm vs 2.37 mm, P<0.001). The highest quartile of EAT thickness (≥2.55 mm) was associated with increased risk of progression to metabolic syndrome (Odds ratio [OR], 3.09; 95% confidence interval [CI], 1.11-8.66) after adjustment for age, smoking, alcohol intake, regular exercise, total energy intake, high sensitive C-reactive protein and homeostasis model assessment of insulin resistance in men. A significant association of EAT with incident metabolic syndrome was not seen in women (OR, 1.25; 95% CI, 0.54-2.90). In conclusion, increased EAT thickness is an independent predictor for incident metabolic syndrome in men.

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