A prospective study of fatty liver index and incident hypertension: The KoGES-ARIRANG study

Ji Hye Huh, Song Vogue Ahn, Sang Baek Koh, Eunhee Choi, Jang Young Kim, Ki Chul Sung, Eung Ju Kim, Jeong Bae Park

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background Although non-alcoholic fatty liver disease is the hepatic manifestation of metabolic syndrome, its influence on hypertension development is poorly understood. We investigated whether fatty liver disease, as assessed by the fatty liver index, could predict the development of hypertension independently of systemic insulin resistance, inflammatory status and adipokine levels. Methods Prospective cohort study of 1,521 adults (484 men and 1037 women) aged 40 to 70 years without baseline hypertension examined. An equation was used to calculate fatty liver index and classify patients as follows: fatty liver index <30, no non-alcoholic fatty liver disease; fatty liver index ≥60, non-alcoholic fatty liver disease; and 30≤ fatty liver index <60, intermediate fatty liver index. Results During an average of 2.6 years of follow-up, 153 subjects (10.06%) developed hypertension. Fatty liver index was positively associated with baseline blood pressure, homeostasis model assessment of insulin resistance, urinary albumin/creatinine excretion, and high sensitivity C-reactive protein. After adjustment for confounding factors, including markers of insulin resistance, systemic inflammation and adiponectin levels, the odds ratio [95% confidence interval] for the incident hypertension increased in a graded manner with fatty liver index (<30 vs. 30-59 vs. ≥60 = 1 vs. 1.83 [1.16∼2.88] vs. 2.09 [1.08∼4.055], respectively). Conclusions Non-alcoholic fatty liver disease assessed by fatty liver index was an independent risk factor for hypertension. Our findings suggest that fatty liver index, a simple surrogate indicator of fatty liver disease, might be useful for identifying subjects at high risk for incident hypertension in clinical practice.

Original languageEnglish
Article numbere0143560
JournalPloS one
Volume10
Issue number11
DOIs
Publication statusPublished - 2015 Nov 1

Fingerprint

fatty liver
Fatty Liver
prospective studies
Liver
hypertension
Prospective Studies
Hypertension
Insulin Resistance
insulin resistance
Liver Diseases
liver diseases
Insulin
Adipokines
Adiponectin
adipokines
C-Reactive Protein
adiponectin
Albumins
Creatinine
C-reactive protein

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Huh, Ji Hye ; Ahn, Song Vogue ; Koh, Sang Baek ; Choi, Eunhee ; Kim, Jang Young ; Sung, Ki Chul ; Kim, Eung Ju ; Park, Jeong Bae. / A prospective study of fatty liver index and incident hypertension : The KoGES-ARIRANG study. In: PloS one. 2015 ; Vol. 10, No. 11.
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abstract = "Background Although non-alcoholic fatty liver disease is the hepatic manifestation of metabolic syndrome, its influence on hypertension development is poorly understood. We investigated whether fatty liver disease, as assessed by the fatty liver index, could predict the development of hypertension independently of systemic insulin resistance, inflammatory status and adipokine levels. Methods Prospective cohort study of 1,521 adults (484 men and 1037 women) aged 40 to 70 years without baseline hypertension examined. An equation was used to calculate fatty liver index and classify patients as follows: fatty liver index <30, no non-alcoholic fatty liver disease; fatty liver index ≥60, non-alcoholic fatty liver disease; and 30≤ fatty liver index <60, intermediate fatty liver index. Results During an average of 2.6 years of follow-up, 153 subjects (10.06{\%}) developed hypertension. Fatty liver index was positively associated with baseline blood pressure, homeostasis model assessment of insulin resistance, urinary albumin/creatinine excretion, and high sensitivity C-reactive protein. After adjustment for confounding factors, including markers of insulin resistance, systemic inflammation and adiponectin levels, the odds ratio [95{\%} confidence interval] for the incident hypertension increased in a graded manner with fatty liver index (<30 vs. 30-59 vs. ≥60 = 1 vs. 1.83 [1.16∼2.88] vs. 2.09 [1.08∼4.055], respectively). Conclusions Non-alcoholic fatty liver disease assessed by fatty liver index was an independent risk factor for hypertension. Our findings suggest that fatty liver index, a simple surrogate indicator of fatty liver disease, might be useful for identifying subjects at high risk for incident hypertension in clinical practice.",
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A prospective study of fatty liver index and incident hypertension : The KoGES-ARIRANG study. / Huh, Ji Hye; Ahn, Song Vogue; Koh, Sang Baek; Choi, Eunhee; Kim, Jang Young; Sung, Ki Chul; Kim, Eung Ju; Park, Jeong Bae.

In: PloS one, Vol. 10, No. 11, e0143560, 01.11.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A prospective study of fatty liver index and incident hypertension

T2 - The KoGES-ARIRANG study

AU - Huh, Ji Hye

AU - Ahn, Song Vogue

AU - Koh, Sang Baek

AU - Choi, Eunhee

AU - Kim, Jang Young

AU - Sung, Ki Chul

AU - Kim, Eung Ju

AU - Park, Jeong Bae

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Background Although non-alcoholic fatty liver disease is the hepatic manifestation of metabolic syndrome, its influence on hypertension development is poorly understood. We investigated whether fatty liver disease, as assessed by the fatty liver index, could predict the development of hypertension independently of systemic insulin resistance, inflammatory status and adipokine levels. Methods Prospective cohort study of 1,521 adults (484 men and 1037 women) aged 40 to 70 years without baseline hypertension examined. An equation was used to calculate fatty liver index and classify patients as follows: fatty liver index <30, no non-alcoholic fatty liver disease; fatty liver index ≥60, non-alcoholic fatty liver disease; and 30≤ fatty liver index <60, intermediate fatty liver index. Results During an average of 2.6 years of follow-up, 153 subjects (10.06%) developed hypertension. Fatty liver index was positively associated with baseline blood pressure, homeostasis model assessment of insulin resistance, urinary albumin/creatinine excretion, and high sensitivity C-reactive protein. After adjustment for confounding factors, including markers of insulin resistance, systemic inflammation and adiponectin levels, the odds ratio [95% confidence interval] for the incident hypertension increased in a graded manner with fatty liver index (<30 vs. 30-59 vs. ≥60 = 1 vs. 1.83 [1.16∼2.88] vs. 2.09 [1.08∼4.055], respectively). Conclusions Non-alcoholic fatty liver disease assessed by fatty liver index was an independent risk factor for hypertension. Our findings suggest that fatty liver index, a simple surrogate indicator of fatty liver disease, might be useful for identifying subjects at high risk for incident hypertension in clinical practice.

AB - Background Although non-alcoholic fatty liver disease is the hepatic manifestation of metabolic syndrome, its influence on hypertension development is poorly understood. We investigated whether fatty liver disease, as assessed by the fatty liver index, could predict the development of hypertension independently of systemic insulin resistance, inflammatory status and adipokine levels. Methods Prospective cohort study of 1,521 adults (484 men and 1037 women) aged 40 to 70 years without baseline hypertension examined. An equation was used to calculate fatty liver index and classify patients as follows: fatty liver index <30, no non-alcoholic fatty liver disease; fatty liver index ≥60, non-alcoholic fatty liver disease; and 30≤ fatty liver index <60, intermediate fatty liver index. Results During an average of 2.6 years of follow-up, 153 subjects (10.06%) developed hypertension. Fatty liver index was positively associated with baseline blood pressure, homeostasis model assessment of insulin resistance, urinary albumin/creatinine excretion, and high sensitivity C-reactive protein. After adjustment for confounding factors, including markers of insulin resistance, systemic inflammation and adiponectin levels, the odds ratio [95% confidence interval] for the incident hypertension increased in a graded manner with fatty liver index (<30 vs. 30-59 vs. ≥60 = 1 vs. 1.83 [1.16∼2.88] vs. 2.09 [1.08∼4.055], respectively). Conclusions Non-alcoholic fatty liver disease assessed by fatty liver index was an independent risk factor for hypertension. Our findings suggest that fatty liver index, a simple surrogate indicator of fatty liver disease, might be useful for identifying subjects at high risk for incident hypertension in clinical practice.

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