A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation

Natalia P. Achkar, Seok Keun Cho, Christian Poulsen, Agustin L. Arce, Delfina A. Re, Axel J. Giudicatti, Elizabeth Karayekov, Moon Young Ryu, Suk Won Choi, Jesper Harholt, Jorge J. Casal, Seong Wook Yang, Pablo A. Manavella

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Achkar et al. show that a nuclear reserve pool of inactive phosphorylated HYL1, an essential cofactor for microRNA biogenesis, is resistant to dark- or shade-induced degradation. Upon light restoration, this HYL1 pool is quickly dephosphorylated to rapidly restore miRNA production and switch the developmental program to light-dependent growth.

Original languageEnglish
Pages (from-to)236-247.e6
JournalDevelopmental Cell
Volume46
Issue number2
DOIs
Publication statusPublished - 2018 Jul 16

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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    Achkar, N. P., Cho, S. K., Poulsen, C., Arce, A. L., Re, D. A., Giudicatti, A. J., Karayekov, E., Ryu, M. Y., Choi, S. W., Harholt, J., Casal, J. J., Yang, S. W., & Manavella, P. A. (2018). A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation. Developmental Cell, 46(2), 236-247.e6. https://doi.org/10.1016/j.devcel.2018.06.014