Abstract
Purpose: S-1 or capecitabine plus oxaliplatin are considered active and tolerable in gastric cancer patients. We conducted a randomized phase II trial in gastric cancer patients to compare the activity and safety of these combinations. Methods: The patients received S-1 at 80 mg/m 2 for 14 days, followed by a 7-day rest period within a 3-week schedule in the S-1/oxaliplatin (SOX) arm, and capecitabine at 2000 mg/m 2 for 14 days, followed by a 7-day rest period within a 3-week schedule in the capecitabine/oxaliplatin (CAPOX) arm. Oxaliplatin 130 mg/m 2 was administered every 3 weeks in both arms. Results: One hundred twenty-nine patients were randomly assigned to SOX (N = 65) or CAPOX (N = 64). The median time to progression and the overall survival were 6.2 and 12.4 months with SOX, respectively; and 7.2 and 13.3 months with CAPOX, respectively. The overall response rates were 40% and 44% for SOX and CAPOX, respectively. The most frequent grade 3 or 4 toxicities were thrombocytopenia (15.4%) for SOX and neutropenia (18.8%) for CAPOX. The median time to 10% deteriorations in global health scores was similar in both arms (SOX, 4.3 months, CAPOX, 4.9 months). Conclusion: Both the SOX and CAPOX regimens were equally active and well tolerated in advanced gastric cancer patients.
Original language | English |
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Pages (from-to) | 518-526 |
Number of pages | 9 |
Journal | European Journal of Cancer |
Volume | 48 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2012 Mar |
Bibliographical note
Funding Information:This study was supported by a grant of the Korea Health 21 R & D Project, Ministry of Health & Welfare, Republic of Korea (0405-BC01-0604-0002).
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research