A randomized phase II trial of S-1-oxaliplatin versus capecitabine- oxaliplatin in advanced gastric cancer

Gun Min Kim, Hei Cheul Jeung, Sun Young Rha, Hyo Song Kim, Inkyung Jung, Byung Ho Nam, Kyung Hee Lee, Hyun Cheol Chung

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Purpose: S-1 or capecitabine plus oxaliplatin are considered active and tolerable in gastric cancer patients. We conducted a randomized phase II trial in gastric cancer patients to compare the activity and safety of these combinations. Methods: The patients received S-1 at 80 mg/m 2 for 14 days, followed by a 7-day rest period within a 3-week schedule in the S-1/oxaliplatin (SOX) arm, and capecitabine at 2000 mg/m 2 for 14 days, followed by a 7-day rest period within a 3-week schedule in the capecitabine/oxaliplatin (CAPOX) arm. Oxaliplatin 130 mg/m 2 was administered every 3 weeks in both arms. Results: One hundred twenty-nine patients were randomly assigned to SOX (N = 65) or CAPOX (N = 64). The median time to progression and the overall survival were 6.2 and 12.4 months with SOX, respectively; and 7.2 and 13.3 months with CAPOX, respectively. The overall response rates were 40% and 44% for SOX and CAPOX, respectively. The most frequent grade 3 or 4 toxicities were thrombocytopenia (15.4%) for SOX and neutropenia (18.8%) for CAPOX. The median time to 10% deteriorations in global health scores was similar in both arms (SOX, 4.3 months, CAPOX, 4.9 months). Conclusion: Both the SOX and CAPOX regimens were equally active and well tolerated in advanced gastric cancer patients.

Original languageEnglish
Pages (from-to)518-526
Number of pages9
JournalEuropean Journal of Cancer
Volume48
Issue number4
DOIs
Publication statusPublished - 2012 Mar 1

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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