A rhodamine-hydroxamic acid-based fluorescent probe for hypochlorous acid and its applications to Biological imagings

Young Keun Yang, Hyungseoph Jason Cho, Jihyun Lee, Injae Shin, Jinsung Tae

Research output: Contribution to journalArticle

240 Citations (Scopus)

Abstract

A new rhodamine-hydroxamic acid-based fluorescent chemosensor for the rapid detection of HOCl in aqueous media was developed. The system, which utilizes an irreversible HOCl-promoted oxidation reaction, responds instantaneously at room temperature with linear proportionality to the amount of HOCl. This system is highly selective for HOCl over other reactive oxygen species (ROS) and highly sensitive in aqueous solutions. Biological imaging studies using living cells and organisms (A549 cells and zebrafish) to detect HOCl are successfully demonstrated.

Original languageEnglish
Pages (from-to)859-861
Number of pages3
JournalOrganic Letters
Volume11
Issue number4
DOIs
Publication statusPublished - 2009 Feb 19

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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