A simplified serological test for leprosy based on a 3,6-di-O-methylglucose-containing synthetic antigen

Sangnae Cho, D. Chatterjee, P. J. Brennan

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The recent advent of synthetic antigens containing the Mycobacterium leprae-specific epitope, 3,6-di-O-methyl-β-D-glucopyranoside, has allowed the development of simple specific serological tests for leprosy. The incorporation of one such product, 8-carbonyloctyl O-[4-O-(3,6-di-O-methyl-β-D-glucopyranosyl)-α-L-rhamnopyra noside]-BSA, into a simple 'spot' test, diffusion-in-gel enzyme-linked immunosorbent assay (ELISA), allowed an over 90% detection rate of untreated lepromatous leprosy, and the results showed good concordance with conventional ELISA based on the native phenolic glycolipid I.

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume35
Issue number1
DOIs
Publication statusPublished - 1986 Jan 1

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Synthetic Vaccines
Serologic Tests
Leprosy
Enzyme-Linked Immunosorbent Assay
Lepromatous Leprosy
Mycobacterium leprae
Immunodiffusion
Glycolipids
Epitopes
3,6-di-O-methylglucose
methylglucoside

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

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A simplified serological test for leprosy based on a 3,6-di-O-methylglucose-containing synthetic antigen. / Cho, Sangnae; Chatterjee, D.; Brennan, P. J.

In: American Journal of Tropical Medicine and Hygiene, Vol. 35, No. 1, 01.01.1986, p. 167-172.

Research output: Contribution to journalArticle

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