A simplified serological test for leprosy based on a 3,6-di-O-methylglucose-containing synthetic antigen

S. N. Cho, D. Chatterjee, P. J. Brennan

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The recent advent of synthetic antigens containing the Mycobacterium leprae-specific epitope, 3,6-di-O-methyl-β-D-glucopyranoside, has allowed the development of simple specific serological tests for leprosy. The incorporation of one such product, 8-carbonyloctyl O-[4-O-(3,6-di-O-methyl-β-D-glucopyranosyl)-α-L-rhamnopyra noside]-BSA, into a simple 'spot' test, diffusion-in-gel enzyme-linked immunosorbent assay (ELISA), allowed an over 90% detection rate of untreated lepromatous leprosy, and the results showed good concordance with conventional ELISA based on the native phenolic glycolipid I.

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume35
Issue number1
DOIs
Publication statusPublished - 1986

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Virology
  • Infectious Diseases

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