TY - JOUR
T1 - A simplified serological test for leprosy based on a 3,6-di-O-methylglucose-containing synthetic antigen
AU - Cho, S. N.
AU - Chatterjee, D.
AU - Brennan, P. J.
PY - 1986
Y1 - 1986
N2 - The recent advent of synthetic antigens containing the Mycobacterium leprae-specific epitope, 3,6-di-O-methyl-β-D-glucopyranoside, has allowed the development of simple specific serological tests for leprosy. The incorporation of one such product, 8-carbonyloctyl O-[4-O-(3,6-di-O-methyl-β-D-glucopyranosyl)-α-L-rhamnopyra noside]-BSA, into a simple 'spot' test, diffusion-in-gel enzyme-linked immunosorbent assay (ELISA), allowed an over 90% detection rate of untreated lepromatous leprosy, and the results showed good concordance with conventional ELISA based on the native phenolic glycolipid I.
AB - The recent advent of synthetic antigens containing the Mycobacterium leprae-specific epitope, 3,6-di-O-methyl-β-D-glucopyranoside, has allowed the development of simple specific serological tests for leprosy. The incorporation of one such product, 8-carbonyloctyl O-[4-O-(3,6-di-O-methyl-β-D-glucopyranosyl)-α-L-rhamnopyra noside]-BSA, into a simple 'spot' test, diffusion-in-gel enzyme-linked immunosorbent assay (ELISA), allowed an over 90% detection rate of untreated lepromatous leprosy, and the results showed good concordance with conventional ELISA based on the native phenolic glycolipid I.
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U2 - 10.4269/ajtmh.1986.35.167
DO - 10.4269/ajtmh.1986.35.167
M3 - Article
C2 - 3080916
AN - SCOPUS:0022607726
SN - 0002-9637
VL - 35
SP - 167
EP - 172
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 1
ER -
