A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure

Joohee Kim; Jihun Park; Young Geun Park; Eunkyung Cha; Minjae Ku; Hyeon Seok An; Kyoung Pil Lee; Man Il Huh; Junmo Kim; Taek Soo Kim; Dai Woo Kim; Hong Kyun Kim; Jang Ung Park

doi:10.1038/s41551-021-00719-8

A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure

Joohee Kim, Jihun Park, Young Geun Park, Eunkyung Cha, Minjae Ku, Hyeon Seok An, Kyoung Pil Lee, Man Il Huh, Junmo Kim, Taek Soo Kim, Dai Woo Kim, Hong Kyun Kim, Jang Ung Park

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Continuous detection of raised intraocular pressure (IOP) could benefit the monitoring of patients with glaucoma. Current contact lenses with embedded sensors for measuring IOP are rigid, bulky, partially block vision or are insufficiently sensitive. Here, we report the design and testing in volunteers of a soft and transparent contact lens for the quantitative monitoring of IOP in real time using a smartphone. The contact lens incorporates a strain sensor, a wireless antenna, capacitors, resistors, stretchable metal interconnects and an integrated circuit for wireless communication. In rabbits, the lens provided measurements that match those of a commercial tonometer. In ten human participants, the lens proved to be safe, and reliably provided accurate quantitative measurements of IOP without inducing inflammation.

Original language	English
Pages (from-to)	772-782
Number of pages	11
Journal	Nature biomedical engineering
Volume	5
Issue number	7
DOIs	https://doi.org/10.1038/s41551-021-00719-8
Publication status	Published - 2021 Jul

Bibliographical note

Funding Information:
This work was supported by the Ministry of Science & ICT (MSIT) and the Ministry of Trade, Industry and Energy (MOTIE) of Korea through the National Research Foundation (2019R1A2B5B03069358 and 2016R1A5A1009926), the Bio & Medical Technology Development Program (2018M3A9F1021649), the Nano Material Technology Development Program (2016M3A7B4910635) and the Technology Innovation Program (20010366 and 20013621, Center for Super Critical Material Industrial Technology). We also acknowledge financial support from the Institute for Basic Science (IBS-R026-D1), the Research Program (2019-22-0228) and the Post Doc Researcher Supporting program of 2019 (2019-12-0010) funded by Yonsei University.

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature Limited.

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
Computer Science Applications

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abstract = "Continuous detection of raised intraocular pressure (IOP) could benefit the monitoring of patients with glaucoma. Current contact lenses with embedded sensors for measuring IOP are rigid, bulky, partially block vision or are insufficiently sensitive. Here, we report the design and testing in volunteers of a soft and transparent contact lens for the quantitative monitoring of IOP in real time using a smartphone. The contact lens incorporates a strain sensor, a wireless antenna, capacitors, resistors, stretchable metal interconnects and an integrated circuit for wireless communication. In rabbits, the lens provided measurements that match those of a commercial tonometer. In ten human participants, the lens proved to be safe, and reliably provided accurate quantitative measurements of IOP without inducing inflammation.",

author = "Joohee Kim and Jihun Park and Park, {Young Geun} and Eunkyung Cha and Minjae Ku and An, {Hyeon Seok} and Lee, {Kyoung Pil} and Huh, {Man Il} and Junmo Kim and Kim, {Taek Soo} and Kim, {Dai Woo} and Kim, {Hong Kyun} and Park, {Jang Ung}",

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A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure

Abstract

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