Background: A number of lasers and light-based devices have been reported as promising treatment options for acne vulgaris. Objective: To evaluate the efficacy and safety of fractional microneedle radiofrequency (MRF) device treatment compared to CO 2 fractional laser system (FS) for the treatment of acne vulgaris. Methods: Twenty healthy subjects underwent full-face treatment for acne vulgaris with CO 2 FS and MRF device. For each subject, two passes of CO 2 FS with a pulse energy setting of 80 mJ and a density of 100 spots/cm 2 were used on one side, and two passes of MRF device with a intensity of 8, density of 25 MTZ/cm 2 , and a depth of 1.5-2.5 mm were used on the other. Patients were evaluated 3 months postoperatively and were also photographed. Results: Most of the patients improved based on clinical and photographic assessments 3 months after the treatment. No significant differences in physician-measured parameters, patient ratings, or intraoperative pain ratings were found, although downtime was significantly longer for the CO 2 FS treated side. Conclusions: MRF device and CO 2 FS can be used for acne vulgaris patients and MRF device is more convenient than CO 2 FS because of its short downtime.
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