A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression

Zhongqiu Zhang, Yian Wang, Christopher R. Herzog, Gongjie Liu, Han Woong Lee, Ronald A. DePinho, Ming You

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Lung cancer is the leading cause of cancer death among both men and women, accounting for more than 28% of all cancer deaths. In fact, more people die of lung cancer than of colon, breast, and prostate cancers combined. Although lung cancer is largely induced by smoking, there is strong evidence for genetic susceptibility and gene-environment interactions in the development of lung cancer. Inbred mouse models offer an effective means of identifying candidate lung cancer susceptibility loci since genetic heterogeneity and enormous variation in exposure levels to environmental agents make it difficult to identify lung cancer susceptibility loci in humans. Papg-1 (pulmonary adenoma progression 1) was previously mapped to a region on mouse chromosome 4. This locus contains a candidate gene, Cdkn2a also referred to as Ink4a/Arf, which dually encodes two established tumor suppressors p16INK4a and ARF. Cdkn2a became a primary candidate for Papg-1 for two reasons: (1) two haplotypes of mouse Cdkn2a were found to segregate with differential genetic susceptibility to lung tumor progression in mice; and (2) in vitro studies showed that the p16INK4a allele from the BALB/cJ mouse had a significantly decreased ability to bind and inhibit CDK6 and to suppress cell growth when compared with the p16INK4a allele from the A/J mouse. Here, we report that mice with a heterozygous deficiency for the A/J Cdkn2a allele were significantly more susceptible to lung tumor progression than mice with a heterozygous deficiency for a BALB/cJ Cdkn2a allele, when compared to their respective wild type mice. These results offer strong evidence that naturally occurring variation of p16INK4a influences susceptibility to enhance lung tumor progression making it a strong candidate for the lung tumor progression locus, Papg-1.

Original languageEnglish
Pages (from-to)5960-5966
Number of pages7
JournalOncogene
Volume21
Issue number38
DOIs
Publication statusPublished - 2002 Jan 1

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Chromosomes, Human, Pair 4
Lung
Lung Neoplasms
Genes
Neoplasms
Alleles
Adenoma
Genetic Predisposition to Disease
Colonic Neoplasms
Prostatic Neoplasms
Breast Neoplasms
Gene-Environment Interaction
Aptitude
Genetic Heterogeneity
Haplotypes
Cause of Death
Smoking

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Zhang, Zhongqiu ; Wang, Yian ; Herzog, Christopher R. ; Liu, Gongjie ; Lee, Han Woong ; DePinho, Ronald A. ; You, Ming. / A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression. In: Oncogene. 2002 ; Vol. 21, No. 38. pp. 5960-5966.
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Zhang, Z, Wang, Y, Herzog, CR, Liu, G, Lee, HW, DePinho, RA & You, M 2002, 'A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression', Oncogene, vol. 21, no. 38, pp. 5960-5966. https://doi.org/10.1038/sj.onc.1205725

A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression. / Zhang, Zhongqiu; Wang, Yian; Herzog, Christopher R.; Liu, Gongjie; Lee, Han Woong; DePinho, Ronald A.; You, Ming.

In: Oncogene, Vol. 21, No. 38, 01.01.2002, p. 5960-5966.

Research output: Contribution to journalArticle

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