The major acidic polysaccharide from the brown alga Laminaria cichorioides is a complex and heterogeneous sulfated fucan. Its preponderant structure is a 2,3-disulfated, 4-linked α-fucose unit. The purified polysaccharide has a potent anticoagulant activity, as estimated by APTT assay (∼40 IU/mg), which is mainly mediated by thrombin inhibition by heparin cofactor II. It also accelerates thrombin and factor Xa inhibition by antithrombin but at a lower potency. Sulfated fucan from L. cichorioides is a promising anticoagulant polysaccharide and a possible alternative for an antithrombotic compound due to its preferential heparin cofactor II-dependent activity.
Bibliographical noteFunding Information:
This investigation was supported in part by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) and the Korea Science and Engineering Foundation (KOSEF) through the Bioproducts Research Center of Yonsei University.
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Organic Chemistry