A sulfated fucan from the brown alga Laminaria cichorioides has mainly heparin cofactor II-dependent anticoagulant activity

Seon Joo Yoon, Yu Ryang Pyun, Jae Kwan Hwang, Paulo A.S. Mourão

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The major acidic polysaccharide from the brown alga Laminaria cichorioides is a complex and heterogeneous sulfated fucan. Its preponderant structure is a 2,3-disulfated, 4-linked α-fucose unit. The purified polysaccharide has a potent anticoagulant activity, as estimated by APTT assay (∼40 IU/mg), which is mainly mediated by thrombin inhibition by heparin cofactor II. It also accelerates thrombin and factor Xa inhibition by antithrombin but at a lower potency. Sulfated fucan from L. cichorioides is a promising anticoagulant polysaccharide and a possible alternative for an antithrombotic compound due to its preferential heparin cofactor II-dependent activity.

Original languageEnglish
Pages (from-to)2326-2330
Number of pages5
JournalCarbohydrate Research
Volume342
Issue number15
DOIs
Publication statusPublished - 2007 Nov 5

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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