A sulfated fucan from the brown alga Laminaria cichorioides has mainly heparin cofactor II-dependent anticoagulant activity

Seon Joo Yoon, Yu Ryang Pyun, Jae-Kwan Hwang, Paulo A.S. Mourão

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The major acidic polysaccharide from the brown alga Laminaria cichorioides is a complex and heterogeneous sulfated fucan. Its preponderant structure is a 2,3-disulfated, 4-linked α-fucose unit. The purified polysaccharide has a potent anticoagulant activity, as estimated by APTT assay (∼40 IU/mg), which is mainly mediated by thrombin inhibition by heparin cofactor II. It also accelerates thrombin and factor Xa inhibition by antithrombin but at a lower potency. Sulfated fucan from L. cichorioides is a promising anticoagulant polysaccharide and a possible alternative for an antithrombotic compound due to its preferential heparin cofactor II-dependent activity.

Original languageEnglish
Pages (from-to)2326-2330
Number of pages5
JournalCarbohydrate Research
Volume342
Issue number15
DOIs
Publication statusPublished - 2007 Nov 5

Fingerprint

Heparin Cofactor II
Laminaria
Phaeophyta
Algae
Anticoagulants
Polysaccharides
Thrombin
Factor Xa
Fucose
Antithrombins
Assays
fucoidan

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

Cite this

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abstract = "The major acidic polysaccharide from the brown alga Laminaria cichorioides is a complex and heterogeneous sulfated fucan. Its preponderant structure is a 2,3-disulfated, 4-linked α-fucose unit. The purified polysaccharide has a potent anticoagulant activity, as estimated by APTT assay (∼40 IU/mg), which is mainly mediated by thrombin inhibition by heparin cofactor II. It also accelerates thrombin and factor Xa inhibition by antithrombin but at a lower potency. Sulfated fucan from L. cichorioides is a promising anticoagulant polysaccharide and a possible alternative for an antithrombotic compound due to its preferential heparin cofactor II-dependent activity.",
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A sulfated fucan from the brown alga Laminaria cichorioides has mainly heparin cofactor II-dependent anticoagulant activity. / Yoon, Seon Joo; Pyun, Yu Ryang; Hwang, Jae-Kwan; Mourão, Paulo A.S.

In: Carbohydrate Research, Vol. 342, No. 15, 05.11.2007, p. 2326-2330.

Research output: Contribution to journalArticle

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AU - Yoon, Seon Joo

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