A symmetric metamaterial element-based RF biosensing scheme is experimentally demonstrated by detecting biomolecular binding between a prostate-specific antigen (PSA) and its antibody. The metamaterial element in a high-impedance microstrip line shows an intrinsic S21 resonance having a Q-factor of 55. The frequency shift with PSA concentration, i.e., 100 ng/ml, 10 ng/ml, and 1 ng/ml, is observed and the changes are δf ≈ 20 MHz, 10 MHz, and 5 MHz, respectively. The proposed biosensor offers advantages of label-free detection, a simple and direct scheme, and cost-efficient fabrication.
Bibliographical noteFunding Information:
This study was supported by grants of Ministry of Health and Welfare, Republic of Korea (the National R&D Program for Cancer Control, No. 1120290, the Korea Health technology R&D Project, No. A111114).
All Science Journal Classification (ASJC) codes
- Physics and Astronomy (miscellaneous)