A symmetric metamaterial element-based RF biosensor for rapid and label-free detection

Hee Jo Lee; Jung Hyun Lee; Hyo Il Jung

doi:10.1063/1.3653959

A symmetric metamaterial element-based RF biosensor for rapid and label-free detection

Hee Jo Lee, Jung Hyun Lee, Hyo Il Jung

Department of Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

A symmetric metamaterial element-based RF biosensing scheme is experimentally demonstrated by detecting biomolecular binding between a prostate-specific antigen (PSA) and its antibody. The metamaterial element in a high-impedance microstrip line shows an intrinsic S₂₁ resonance having a Q-factor of 55. The frequency shift with PSA concentration, i.e., 100 ng/ml, 10 ng/ml, and 1 ng/ml, is observed and the changes are δf ≈ 20 MHz, 10 MHz, and 5 MHz, respectively. The proposed biosensor offers advantages of label-free detection, a simple and direct scheme, and cost-efficient fabrication.

Original language	English
Article number	163703
Journal	Applied Physics Letters
Volume	99
Issue number	16
DOIs	https://doi.org/10.1063/1.3653959
Publication status	Published - 2011 Oct 17

Bibliographical note

Funding Information:
This study was supported by grants of Ministry of Health and Welfare, Republic of Korea (the National R&D Program for Cancer Control, No. 1120290, the Korea Health technology R&D Project, No. A111114).

All Science Journal Classification (ASJC) codes

Physics and Astronomy (miscellaneous)

Access to Document

10.1063/1.3653959

Cite this

@article{57d12d30132141999a51b9a5220cb003,

title = "A symmetric metamaterial element-based RF biosensor for rapid and label-free detection",

abstract = "A symmetric metamaterial element-based RF biosensing scheme is experimentally demonstrated by detecting biomolecular binding between a prostate-specific antigen (PSA) and its antibody. The metamaterial element in a high-impedance microstrip line shows an intrinsic S21 resonance having a Q-factor of 55. The frequency shift with PSA concentration, i.e., 100 ng/ml, 10 ng/ml, and 1 ng/ml, is observed and the changes are δf ≈ 20 MHz, 10 MHz, and 5 MHz, respectively. The proposed biosensor offers advantages of label-free detection, a simple and direct scheme, and cost-efficient fabrication.",

author = "Lee, {Hee Jo} and Lee, {Jung Hyun} and Jung, {Hyo Il}",

note = "Funding Information: This study was supported by grants of Ministry of Health and Welfare, Republic of Korea (the National R&D Program for Cancer Control, No. 1120290, the Korea Health technology R&D Project, No. A111114). ",

year = "2011",

month = oct,

day = "17",

doi = "10.1063/1.3653959",

language = "English",

volume = "99",

journal = "Applied Physics Letters",

issn = "0003-6951",

publisher = "American Institute of Physics Publising LLC",

number = "16",

}

TY - JOUR

T1 - A symmetric metamaterial element-based RF biosensor for rapid and label-free detection

AU - Lee, Hee Jo

AU - Lee, Jung Hyun

AU - Jung, Hyo Il

N1 - Funding Information: This study was supported by grants of Ministry of Health and Welfare, Republic of Korea (the National R&D Program for Cancer Control, No. 1120290, the Korea Health technology R&D Project, No. A111114).

PY - 2011/10/17

Y1 - 2011/10/17

N2 - A symmetric metamaterial element-based RF biosensing scheme is experimentally demonstrated by detecting biomolecular binding between a prostate-specific antigen (PSA) and its antibody. The metamaterial element in a high-impedance microstrip line shows an intrinsic S21 resonance having a Q-factor of 55. The frequency shift with PSA concentration, i.e., 100 ng/ml, 10 ng/ml, and 1 ng/ml, is observed and the changes are δf ≈ 20 MHz, 10 MHz, and 5 MHz, respectively. The proposed biosensor offers advantages of label-free detection, a simple and direct scheme, and cost-efficient fabrication.

AB - A symmetric metamaterial element-based RF biosensing scheme is experimentally demonstrated by detecting biomolecular binding between a prostate-specific antigen (PSA) and its antibody. The metamaterial element in a high-impedance microstrip line shows an intrinsic S21 resonance having a Q-factor of 55. The frequency shift with PSA concentration, i.e., 100 ng/ml, 10 ng/ml, and 1 ng/ml, is observed and the changes are δf ≈ 20 MHz, 10 MHz, and 5 MHz, respectively. The proposed biosensor offers advantages of label-free detection, a simple and direct scheme, and cost-efficient fabrication.

UR - http://www.scopus.com/inward/record.url?scp=80155137448&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80155137448&partnerID=8YFLogxK

U2 - 10.1063/1.3653959

DO - 10.1063/1.3653959

M3 - Article

AN - SCOPUS:80155137448

SN - 0003-6951

VL - 99

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 16

M1 - 163703

ER -

A symmetric metamaterial element-based RF biosensor for rapid and label-free detection

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this