A synthetic DNA walker for molecular transport

Jong Shik Shin, Niles A. Pierce

Research output: Contribution to journalArticle

497 Citations (Scopus)

Abstract

Inspired by kinesin movement along a microtubule, we demonstrate a processive bipedal DNA walker. Powered by externally controlled DNA fuel strands, the walker locomotes with a 5 nm stride by advancing the trailing foot to the lead at each step. Real-time monitoring of specific bidirectional walker movement is achieved via multiplexed fluorescence quenching.

Original languageEnglish
Pages (from-to)10834-10835
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number35
DOIs
Publication statusPublished - 2004 Sep 8

Fingerprint

DNA
Kinesin
Microtubules
Foot
Quenching
Lead
Fluorescence
Monitoring

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Shin, Jong Shik ; Pierce, Niles A. / A synthetic DNA walker for molecular transport. In: Journal of the American Chemical Society. 2004 ; Vol. 126, No. 35. pp. 10834-10835.
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A synthetic DNA walker for molecular transport. / Shin, Jong Shik; Pierce, Niles A.

In: Journal of the American Chemical Society, Vol. 126, No. 35, 08.09.2004, p. 10834-10835.

Research output: Contribution to journalArticle

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