Abstract
Background: The hepatitis C pandemic has been systematically studied and characterized in North America and Europe, but this important public health problem has not received equivalent attention in other regions. Aim: The objective of this systematic review was to characterize hepatitis C virus (HCV) epidemiology in selected countries of Asia, Australia and Egypt, i.e. in a geographical area inhabited by over 40% of the global population. Methodology: Data references were identified through indexed journals and non-indexed sources. In this work, 7770 articles were reviewed and 690 were selected based on their relevance. Results: We estimated that 49.3-64.0 million adults in Asia, Australia and Egypt are anti-HCV positive. China alone has more HCV infections than all of Europe or the Americas. While most countries had prevalence rates from 1 to 2% we documented several with relatively high prevalence rates, including Egypt (15%), Pakistan (4.7%) and Taiwan (4.4%). Nosocomial infection, blood transfusion (before screening) and injection drug use were identified as common risk factors in the region. Genotype 1 was common in Australia, China, Taiwan and other countries in North Asia, while genotype 6 was found in Vietnam and other Southeast Asian countries. In India and Pakistan genotype 3 was predominant, while genotype 4 was found in Middle Eastern countries such as Egypt, Saudi Arabia and Syria. Conclusion: We recommend implementation of surveillance systems to guide effective public health policy that may lead to the eventual curtailment of the spread of this pandemic infection.
| Original language | English |
|---|---|
| Pages (from-to) | 61-80 |
| Number of pages | 20 |
| Journal | Liver International |
| Volume | 31 |
| Issue number | SUPPL. 2 |
| DOIs | |
| Publication status | Published - 2011 Jul 1 |
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All Science Journal Classification (ASJC) codes
- Hepatology
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A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt. / Sievert, William; Altraif, Ibrahim; Razavi, Homie A.; Abdo, Ayman; Ahmed, Ezzat Ali; Alomair, Ahmed; Amarapurkar, Deepak; Chen, Chien Hung; Dou, Xiaoguang; El Khayat, Hisham; elShazly, Mohamed; Esmat, Gamal; Guan, Richard; Han, Kwang Hyub; Koike, Kazuhiko; Largen, Angela; Mccaughan, Geoff; Mogawer, Sherif; Monis, Ali; Nawaz, Arif; Piratvisuth, Teerha; Sanai, Faisal M.; Sharara, Ala I.; Sibbel, Scott; Sood, Ajit; Suh, Dong Jin; Wallace, Carolyn; Young, Kendra; Negro, Francesco.
In: Liver International, Vol. 31, No. SUPPL. 2, 01.07.2011, p. 61-80.Research output: Contribution to journal › Article
TY - JOUR
T1 - A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt
AU - Sievert, William
AU - Altraif, Ibrahim
AU - Razavi, Homie A.
AU - Abdo, Ayman
AU - Ahmed, Ezzat Ali
AU - Alomair, Ahmed
AU - Amarapurkar, Deepak
AU - Chen, Chien Hung
AU - Dou, Xiaoguang
AU - El Khayat, Hisham
AU - elShazly, Mohamed
AU - Esmat, Gamal
AU - Guan, Richard
AU - Han, Kwang Hyub
AU - Koike, Kazuhiko
AU - Largen, Angela
AU - Mccaughan, Geoff
AU - Mogawer, Sherif
AU - Monis, Ali
AU - Nawaz, Arif
AU - Piratvisuth, Teerha
AU - Sanai, Faisal M.
AU - Sharara, Ala I.
AU - Sibbel, Scott
AU - Sood, Ajit
AU - Suh, Dong Jin
AU - Wallace, Carolyn
AU - Young, Kendra
AU - Negro, Francesco
PY - 2011/7/1
Y1 - 2011/7/1
N2 - Background: The hepatitis C pandemic has been systematically studied and characterized in North America and Europe, but this important public health problem has not received equivalent attention in other regions. Aim: The objective of this systematic review was to characterize hepatitis C virus (HCV) epidemiology in selected countries of Asia, Australia and Egypt, i.e. in a geographical area inhabited by over 40% of the global population. Methodology: Data references were identified through indexed journals and non-indexed sources. In this work, 7770 articles were reviewed and 690 were selected based on their relevance. Results: We estimated that 49.3-64.0 million adults in Asia, Australia and Egypt are anti-HCV positive. China alone has more HCV infections than all of Europe or the Americas. While most countries had prevalence rates from 1 to 2% we documented several with relatively high prevalence rates, including Egypt (15%), Pakistan (4.7%) and Taiwan (4.4%). Nosocomial infection, blood transfusion (before screening) and injection drug use were identified as common risk factors in the region. Genotype 1 was common in Australia, China, Taiwan and other countries in North Asia, while genotype 6 was found in Vietnam and other Southeast Asian countries. In India and Pakistan genotype 3 was predominant, while genotype 4 was found in Middle Eastern countries such as Egypt, Saudi Arabia and Syria. Conclusion: We recommend implementation of surveillance systems to guide effective public health policy that may lead to the eventual curtailment of the spread of this pandemic infection.
AB - Background: The hepatitis C pandemic has been systematically studied and characterized in North America and Europe, but this important public health problem has not received equivalent attention in other regions. Aim: The objective of this systematic review was to characterize hepatitis C virus (HCV) epidemiology in selected countries of Asia, Australia and Egypt, i.e. in a geographical area inhabited by over 40% of the global population. Methodology: Data references were identified through indexed journals and non-indexed sources. In this work, 7770 articles were reviewed and 690 were selected based on their relevance. Results: We estimated that 49.3-64.0 million adults in Asia, Australia and Egypt are anti-HCV positive. China alone has more HCV infections than all of Europe or the Americas. While most countries had prevalence rates from 1 to 2% we documented several with relatively high prevalence rates, including Egypt (15%), Pakistan (4.7%) and Taiwan (4.4%). Nosocomial infection, blood transfusion (before screening) and injection drug use were identified as common risk factors in the region. Genotype 1 was common in Australia, China, Taiwan and other countries in North Asia, while genotype 6 was found in Vietnam and other Southeast Asian countries. In India and Pakistan genotype 3 was predominant, while genotype 4 was found in Middle Eastern countries such as Egypt, Saudi Arabia and Syria. Conclusion: We recommend implementation of surveillance systems to guide effective public health policy that may lead to the eventual curtailment of the spread of this pandemic infection.
UR - http://www.scopus.com/inward/record.url?scp=79958698124&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958698124&partnerID=8YFLogxK
U2 - 10.1111/j.1478-3231.2011.02540.x
DO - 10.1111/j.1478-3231.2011.02540.x
M3 - Article
C2 - 21651703
AN - SCOPUS:79958698124
VL - 31
SP - 61
EP - 80
JO - Liver International
JF - Liver International
SN - 1478-3223
IS - SUPPL. 2
ER -