A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt

William Sievert, Ibrahim Altraif, Homie A. Razavi, Ayman Abdo, Ezzat Ali Ahmed, Ahmed Alomair, Deepak Amarapurkar, Chien Hung Chen, Xiaoguang Dou, Hisham El Khayat, Mohamed elShazly, Gamal Esmat, Richard Guan, Kwang Hyub Han, Kazuhiko Koike, Angela Largen, Geoff Mccaughan, Sherif Mogawer, Ali Monis, Arif NawazTeerha Piratvisuth, Faisal M. Sanai, Ala I. Sharara, Scott Sibbel, Ajit Sood, Dong Jin Suh, Carolyn Wallace, Kendra Young, Francesco Negro

Research output: Contribution to journalArticle

360 Citations (Scopus)

Abstract

Background: The hepatitis C pandemic has been systematically studied and characterized in North America and Europe, but this important public health problem has not received equivalent attention in other regions. Aim: The objective of this systematic review was to characterize hepatitis C virus (HCV) epidemiology in selected countries of Asia, Australia and Egypt, i.e. in a geographical area inhabited by over 40% of the global population. Methodology: Data references were identified through indexed journals and non-indexed sources. In this work, 7770 articles were reviewed and 690 were selected based on their relevance. Results: We estimated that 49.3-64.0 million adults in Asia, Australia and Egypt are anti-HCV positive. China alone has more HCV infections than all of Europe or the Americas. While most countries had prevalence rates from 1 to 2% we documented several with relatively high prevalence rates, including Egypt (15%), Pakistan (4.7%) and Taiwan (4.4%). Nosocomial infection, blood transfusion (before screening) and injection drug use were identified as common risk factors in the region. Genotype 1 was common in Australia, China, Taiwan and other countries in North Asia, while genotype 6 was found in Vietnam and other Southeast Asian countries. In India and Pakistan genotype 3 was predominant, while genotype 4 was found in Middle Eastern countries such as Egypt, Saudi Arabia and Syria. Conclusion: We recommend implementation of surveillance systems to guide effective public health policy that may lead to the eventual curtailment of the spread of this pandemic infection.

Original languageEnglish
Pages (from-to)61-80
Number of pages20
JournalLiver International
Volume31
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 2011 Jul 1

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Egypt
Hepacivirus
Epidemiology
Genotype
Pakistan
Pandemics
Taiwan
China
Public Health
Northern Asia
Syria
Preclinical Drug Evaluations
Saudi Arabia
Vietnam
Virus Diseases
Public Policy
Hepatitis C
Cross Infection
Health Policy
North America

All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

Sievert, W., Altraif, I., Razavi, H. A., Abdo, A., Ahmed, E. A., Alomair, A., ... Negro, F. (2011). A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt. Liver International, 31(SUPPL. 2), 61-80. https://doi.org/10.1111/j.1478-3231.2011.02540.x
Sievert, William ; Altraif, Ibrahim ; Razavi, Homie A. ; Abdo, Ayman ; Ahmed, Ezzat Ali ; Alomair, Ahmed ; Amarapurkar, Deepak ; Chen, Chien Hung ; Dou, Xiaoguang ; El Khayat, Hisham ; elShazly, Mohamed ; Esmat, Gamal ; Guan, Richard ; Han, Kwang Hyub ; Koike, Kazuhiko ; Largen, Angela ; Mccaughan, Geoff ; Mogawer, Sherif ; Monis, Ali ; Nawaz, Arif ; Piratvisuth, Teerha ; Sanai, Faisal M. ; Sharara, Ala I. ; Sibbel, Scott ; Sood, Ajit ; Suh, Dong Jin ; Wallace, Carolyn ; Young, Kendra ; Negro, Francesco. / A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt. In: Liver International. 2011 ; Vol. 31, No. SUPPL. 2. pp. 61-80.
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abstract = "Background: The hepatitis C pandemic has been systematically studied and characterized in North America and Europe, but this important public health problem has not received equivalent attention in other regions. Aim: The objective of this systematic review was to characterize hepatitis C virus (HCV) epidemiology in selected countries of Asia, Australia and Egypt, i.e. in a geographical area inhabited by over 40{\%} of the global population. Methodology: Data references were identified through indexed journals and non-indexed sources. In this work, 7770 articles were reviewed and 690 were selected based on their relevance. Results: We estimated that 49.3-64.0 million adults in Asia, Australia and Egypt are anti-HCV positive. China alone has more HCV infections than all of Europe or the Americas. While most countries had prevalence rates from 1 to 2{\%} we documented several with relatively high prevalence rates, including Egypt (15{\%}), Pakistan (4.7{\%}) and Taiwan (4.4{\%}). Nosocomial infection, blood transfusion (before screening) and injection drug use were identified as common risk factors in the region. Genotype 1 was common in Australia, China, Taiwan and other countries in North Asia, while genotype 6 was found in Vietnam and other Southeast Asian countries. In India and Pakistan genotype 3 was predominant, while genotype 4 was found in Middle Eastern countries such as Egypt, Saudi Arabia and Syria. Conclusion: We recommend implementation of surveillance systems to guide effective public health policy that may lead to the eventual curtailment of the spread of this pandemic infection.",
author = "William Sievert and Ibrahim Altraif and Razavi, {Homie A.} and Ayman Abdo and Ahmed, {Ezzat Ali} and Ahmed Alomair and Deepak Amarapurkar and Chen, {Chien Hung} and Xiaoguang Dou and {El Khayat}, Hisham and Mohamed elShazly and Gamal Esmat and Richard Guan and Han, {Kwang Hyub} and Kazuhiko Koike and Angela Largen and Geoff Mccaughan and Sherif Mogawer and Ali Monis and Arif Nawaz and Teerha Piratvisuth and Sanai, {Faisal M.} and Sharara, {Ala I.} and Scott Sibbel and Ajit Sood and Suh, {Dong Jin} and Carolyn Wallace and Kendra Young and Francesco Negro",
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Sievert, W, Altraif, I, Razavi, HA, Abdo, A, Ahmed, EA, Alomair, A, Amarapurkar, D, Chen, CH, Dou, X, El Khayat, H, elShazly, M, Esmat, G, Guan, R, Han, KH, Koike, K, Largen, A, Mccaughan, G, Mogawer, S, Monis, A, Nawaz, A, Piratvisuth, T, Sanai, FM, Sharara, AI, Sibbel, S, Sood, A, Suh, DJ, Wallace, C, Young, K & Negro, F 2011, 'A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt', Liver International, vol. 31, no. SUPPL. 2, pp. 61-80. https://doi.org/10.1111/j.1478-3231.2011.02540.x

A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt. / Sievert, William; Altraif, Ibrahim; Razavi, Homie A.; Abdo, Ayman; Ahmed, Ezzat Ali; Alomair, Ahmed; Amarapurkar, Deepak; Chen, Chien Hung; Dou, Xiaoguang; El Khayat, Hisham; elShazly, Mohamed; Esmat, Gamal; Guan, Richard; Han, Kwang Hyub; Koike, Kazuhiko; Largen, Angela; Mccaughan, Geoff; Mogawer, Sherif; Monis, Ali; Nawaz, Arif; Piratvisuth, Teerha; Sanai, Faisal M.; Sharara, Ala I.; Sibbel, Scott; Sood, Ajit; Suh, Dong Jin; Wallace, Carolyn; Young, Kendra; Negro, Francesco.

In: Liver International, Vol. 31, No. SUPPL. 2, 01.07.2011, p. 61-80.

Research output: Contribution to journalArticle

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T1 - A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt

AU - Sievert, William

AU - Altraif, Ibrahim

AU - Razavi, Homie A.

AU - Abdo, Ayman

AU - Ahmed, Ezzat Ali

AU - Alomair, Ahmed

AU - Amarapurkar, Deepak

AU - Chen, Chien Hung

AU - Dou, Xiaoguang

AU - El Khayat, Hisham

AU - elShazly, Mohamed

AU - Esmat, Gamal

AU - Guan, Richard

AU - Han, Kwang Hyub

AU - Koike, Kazuhiko

AU - Largen, Angela

AU - Mccaughan, Geoff

AU - Mogawer, Sherif

AU - Monis, Ali

AU - Nawaz, Arif

AU - Piratvisuth, Teerha

AU - Sanai, Faisal M.

AU - Sharara, Ala I.

AU - Sibbel, Scott

AU - Sood, Ajit

AU - Suh, Dong Jin

AU - Wallace, Carolyn

AU - Young, Kendra

AU - Negro, Francesco

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Background: The hepatitis C pandemic has been systematically studied and characterized in North America and Europe, but this important public health problem has not received equivalent attention in other regions. Aim: The objective of this systematic review was to characterize hepatitis C virus (HCV) epidemiology in selected countries of Asia, Australia and Egypt, i.e. in a geographical area inhabited by over 40% of the global population. Methodology: Data references were identified through indexed journals and non-indexed sources. In this work, 7770 articles were reviewed and 690 were selected based on their relevance. Results: We estimated that 49.3-64.0 million adults in Asia, Australia and Egypt are anti-HCV positive. China alone has more HCV infections than all of Europe or the Americas. While most countries had prevalence rates from 1 to 2% we documented several with relatively high prevalence rates, including Egypt (15%), Pakistan (4.7%) and Taiwan (4.4%). Nosocomial infection, blood transfusion (before screening) and injection drug use were identified as common risk factors in the region. Genotype 1 was common in Australia, China, Taiwan and other countries in North Asia, while genotype 6 was found in Vietnam and other Southeast Asian countries. In India and Pakistan genotype 3 was predominant, while genotype 4 was found in Middle Eastern countries such as Egypt, Saudi Arabia and Syria. Conclusion: We recommend implementation of surveillance systems to guide effective public health policy that may lead to the eventual curtailment of the spread of this pandemic infection.

AB - Background: The hepatitis C pandemic has been systematically studied and characterized in North America and Europe, but this important public health problem has not received equivalent attention in other regions. Aim: The objective of this systematic review was to characterize hepatitis C virus (HCV) epidemiology in selected countries of Asia, Australia and Egypt, i.e. in a geographical area inhabited by over 40% of the global population. Methodology: Data references were identified through indexed journals and non-indexed sources. In this work, 7770 articles were reviewed and 690 were selected based on their relevance. Results: We estimated that 49.3-64.0 million adults in Asia, Australia and Egypt are anti-HCV positive. China alone has more HCV infections than all of Europe or the Americas. While most countries had prevalence rates from 1 to 2% we documented several with relatively high prevalence rates, including Egypt (15%), Pakistan (4.7%) and Taiwan (4.4%). Nosocomial infection, blood transfusion (before screening) and injection drug use were identified as common risk factors in the region. Genotype 1 was common in Australia, China, Taiwan and other countries in North Asia, while genotype 6 was found in Vietnam and other Southeast Asian countries. In India and Pakistan genotype 3 was predominant, while genotype 4 was found in Middle Eastern countries such as Egypt, Saudi Arabia and Syria. Conclusion: We recommend implementation of surveillance systems to guide effective public health policy that may lead to the eventual curtailment of the spread of this pandemic infection.

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Sievert W, Altraif I, Razavi HA, Abdo A, Ahmed EA, Alomair A et al. A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt. Liver International. 2011 Jul 1;31(SUPPL. 2):61-80. https://doi.org/10.1111/j.1478-3231.2011.02540.x