A systematic study of core size and coating thickness on manganese-doped nanocrystals for high T2 relaxivity as magnetic resonance contrast agent

Joseph Park; Byunghoon Kang; Bongjune Kim; Jin Suck Suh; Yong Min Huh; Seungjoo Haam

doi:10.1186/s40580-014-0032-4

A systematic study of core size and coating thickness on manganese-doped nanocrystals for high T2 relaxivity as magnetic resonance contrast agent

Joseph Park, Byunghoon Kang, Bongjune Kim, Jin Suck Suh, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We describe a systematic study of coating thickness and their effect on different core sizes for the optimized preparation of highly sensitive manganese-doped magnetic nanocrystals (MnMNCs) to be served as magnetic resonance (MR) contrast agent. From these efforts, MnMNCs with 12 nm core and DA-PEG2k coating demonstrated that T2 relaxivity (r2) was increased by 7.29-fold (r2 value: 452 mM⁻¹ s⁻¹) compare to conventional iron oxide (CLIO) and remarkable colloidal stability in various physiological conditions. Further in vitro cellular MR imaging results showed that MnMNC-PEGs were biocompatible and well suited for medical applications. This study will provide a useful synthetic strategy for the development of highly effective MR contrast agents.

Original language	English
Article number	3
Journal	Nano Convergence
Volume	2
Issue number	1
DOIs	https://doi.org/10.1186/s40580-014-0032-4
Publication status	Published - 2015 Dec

Bibliographical note

Publisher Copyright:
© 2015, Park et al.; licensee Springer.

All Science Journal Classification (ASJC) codes

Materials Science(all)
Engineering(all)

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10.1186/s40580-014-0032-4

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abstract = "We describe a systematic study of coating thickness and their effect on different core sizes for the optimized preparation of highly sensitive manganese-doped magnetic nanocrystals (MnMNCs) to be served as magnetic resonance (MR) contrast agent. From these efforts, MnMNCs with 12 nm core and DA-PEG2k coating demonstrated that T2 relaxivity (r2) was increased by 7.29-fold (r2 value: 452 mM−1 s−1) compare to conventional iron oxide (CLIO) and remarkable colloidal stability in various physiological conditions. Further in vitro cellular MR imaging results showed that MnMNC-PEGs were biocompatible and well suited for medical applications. This study will provide a useful synthetic strategy for the development of highly effective MR contrast agents.",

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AU - Park, Joseph

AU - Kang, Byunghoon

AU - Kim, Bongjune

AU - Suh, Jin Suck

AU - Huh, Yong Min

AU - Haam, Seungjoo

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A systematic study of core size and coating thickness on manganese-doped nanocrystals for high T2 relaxivity as magnetic resonance contrast agent

Abstract

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