A taller-than-wide shape in thyroid nodules in transverse and longitudinal ultrasonographic planes and the prediction of malignancy

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Abstract

Background: A "taller-than-wide" shape is associated with thyroid malignancy, but taller-than-wide in which plane is most accurate is unclear. We determined in which ultrasonography (US) plane a taller-than-wide shape is most predictive of malignancy. Methods: A total of 471 thyroid nodules from 435 patients were studied. The final diagnosis was based on histopathology in 145 nodules in 120 patients, and cytology in the remaining patients. A taller-than-wide shape was defined as a ratio of ≥1, calculated by dividing the anteroposterior diameter by the transverse diameter. Three criteria were formulated as follows: criterion 1, a taller-than-wide in any plane as a suspicious feature; criterion 2, that in the transverse plane; criterion 3, that in the longitudinal plane. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the receiver operating characteristic curve (Az) were compared among the three criteria. Result: Of the 471 lesions, 125 (26.5%) were classified as malignant, and 346 (73.5%) were classified as benign. Criterion 1 showed high sensitivity (68%) and negative predictive value (87.7%), whereas criteria 2 and 3 showed high specificity (83.5% and 94.5%, respectively). The Az vale of criterion 1 was significantly higher than criteria 2 and 3 (p values = 0.0061 and 0.0362, respectively). Conclusions: A taller-than-wide shape was a useful US feature for predicting thyroid malignancy. Criterion 1, a taller-than-wide shape in either transverse or longitudinal plane, was most accurate and sensitive for predicting thyroid malignancy among the three criteria.

Original languageEnglish
Pages (from-to)1249-1253
Number of pages5
JournalThyroid
Volume21
Issue number11
DOIs
Publication statusPublished - 2011 Nov 1

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Thyroid Nodule
Thyroid Gland
Ultrasonography
Neoplasms
ROC Curve
Cell Biology
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

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title = "A taller-than-wide shape in thyroid nodules in transverse and longitudinal ultrasonographic planes and the prediction of malignancy",
abstract = "Background: A {"}taller-than-wide{"} shape is associated with thyroid malignancy, but taller-than-wide in which plane is most accurate is unclear. We determined in which ultrasonography (US) plane a taller-than-wide shape is most predictive of malignancy. Methods: A total of 471 thyroid nodules from 435 patients were studied. The final diagnosis was based on histopathology in 145 nodules in 120 patients, and cytology in the remaining patients. A taller-than-wide shape was defined as a ratio of ≥1, calculated by dividing the anteroposterior diameter by the transverse diameter. Three criteria were formulated as follows: criterion 1, a taller-than-wide in any plane as a suspicious feature; criterion 2, that in the transverse plane; criterion 3, that in the longitudinal plane. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the receiver operating characteristic curve (Az) were compared among the three criteria. Result: Of the 471 lesions, 125 (26.5{\%}) were classified as malignant, and 346 (73.5{\%}) were classified as benign. Criterion 1 showed high sensitivity (68{\%}) and negative predictive value (87.7{\%}), whereas criteria 2 and 3 showed high specificity (83.5{\%} and 94.5{\%}, respectively). The Az vale of criterion 1 was significantly higher than criteria 2 and 3 (p values = 0.0061 and 0.0362, respectively). Conclusions: A taller-than-wide shape was a useful US feature for predicting thyroid malignancy. Criterion 1, a taller-than-wide shape in either transverse or longitudinal plane, was most accurate and sensitive for predicting thyroid malignancy among the three criteria.",
author = "Moon, {Hee Jung} and Kwak, {Jin Young} and Kim, {Eun Kyung} and Kim, {Min Jung}",
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AU - Moon, Hee Jung

AU - Kwak, Jin Young

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AU - Kim, Min Jung

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N2 - Background: A "taller-than-wide" shape is associated with thyroid malignancy, but taller-than-wide in which plane is most accurate is unclear. We determined in which ultrasonography (US) plane a taller-than-wide shape is most predictive of malignancy. Methods: A total of 471 thyroid nodules from 435 patients were studied. The final diagnosis was based on histopathology in 145 nodules in 120 patients, and cytology in the remaining patients. A taller-than-wide shape was defined as a ratio of ≥1, calculated by dividing the anteroposterior diameter by the transverse diameter. Three criteria were formulated as follows: criterion 1, a taller-than-wide in any plane as a suspicious feature; criterion 2, that in the transverse plane; criterion 3, that in the longitudinal plane. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the receiver operating characteristic curve (Az) were compared among the three criteria. Result: Of the 471 lesions, 125 (26.5%) were classified as malignant, and 346 (73.5%) were classified as benign. Criterion 1 showed high sensitivity (68%) and negative predictive value (87.7%), whereas criteria 2 and 3 showed high specificity (83.5% and 94.5%, respectively). The Az vale of criterion 1 was significantly higher than criteria 2 and 3 (p values = 0.0061 and 0.0362, respectively). Conclusions: A taller-than-wide shape was a useful US feature for predicting thyroid malignancy. Criterion 1, a taller-than-wide shape in either transverse or longitudinal plane, was most accurate and sensitive for predicting thyroid malignancy among the three criteria.

AB - Background: A "taller-than-wide" shape is associated with thyroid malignancy, but taller-than-wide in which plane is most accurate is unclear. We determined in which ultrasonography (US) plane a taller-than-wide shape is most predictive of malignancy. Methods: A total of 471 thyroid nodules from 435 patients were studied. The final diagnosis was based on histopathology in 145 nodules in 120 patients, and cytology in the remaining patients. A taller-than-wide shape was defined as a ratio of ≥1, calculated by dividing the anteroposterior diameter by the transverse diameter. Three criteria were formulated as follows: criterion 1, a taller-than-wide in any plane as a suspicious feature; criterion 2, that in the transverse plane; criterion 3, that in the longitudinal plane. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the receiver operating characteristic curve (Az) were compared among the three criteria. Result: Of the 471 lesions, 125 (26.5%) were classified as malignant, and 346 (73.5%) were classified as benign. Criterion 1 showed high sensitivity (68%) and negative predictive value (87.7%), whereas criteria 2 and 3 showed high specificity (83.5% and 94.5%, respectively). The Az vale of criterion 1 was significantly higher than criteria 2 and 3 (p values = 0.0061 and 0.0362, respectively). Conclusions: A taller-than-wide shape was a useful US feature for predicting thyroid malignancy. Criterion 1, a taller-than-wide shape in either transverse or longitudinal plane, was most accurate and sensitive for predicting thyroid malignancy among the three criteria.

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