A thiol-activated fluorogenic probe for detection of a target protein

Hui Li, Chang Hee Lee, Injae Shin

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


A novel fluorogenic probe for facile and efficient detection of a target protein that binds to a bioactive small molecule was developed. The probe was composed of a thiol-activated fluorogenic moiety bearing an alkyne tag and a protein binding ligand linked to a photoreactive protein labeling group. The new probe in conjunction with affinity chromatography and mass spectrometry was utilized to identify a target protein in cell lysates.

Original languageEnglish
Pages (from-to)6336-6339
Number of pages4
JournalChemical Communications
Issue number43
Publication statusPublished - 2022 May 6

Bibliographical note

Publisher Copyright:
© 2022 The Royal Society of Chemistry

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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