A three-dimensional and bevel-angled ultrahigh aspect ratio microneedle for minimally invasive and painless blood sampling

Dae Sik Lee, Cheng Guo Li, Chunhwa Ihm, Hyungil Jung

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In spite of the invasiveness and pain related with it, blood sampling is necessary in point-of-care systems to obtain biochemical information. In this context, a substitute micro-scale needle for minimally invasive and painless blood sampling has been developed. In conventional microneedle fabrication methods, it is difficult to combine the features of a sharp tip shape, appropriate length, and a hollow structure simultaneously. Thus, here we report a sharp, hollow, and ultrahigh aspect ratio microneedle long enough to get to the blood vessels which is capable of minimizing the pain caused by nerve pricking. It is equipped with a fluidic system to handle blood. The structure of the microneedle was precisely formed using a drawing lithography method and a sharp angle tip was formed using a laser-cutting method.

Original languageEnglish
Pages (from-to)384-390
Number of pages7
JournalSensors and Actuators, B: Chemical
Volume255
DOIs
Publication statusPublished - 2018 Feb 1

Fingerprint

blood
aspect ratio
Aspect ratio
Blood
pain
sampling
Sampling
hollow
laser cutting
blood vessels
fluidics
Blood vessels
nerves
Fluidics
needles
Needles
Lithography
lithography
substitutes
Fabrication

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

Cite this

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abstract = "In spite of the invasiveness and pain related with it, blood sampling is necessary in point-of-care systems to obtain biochemical information. In this context, a substitute micro-scale needle for minimally invasive and painless blood sampling has been developed. In conventional microneedle fabrication methods, it is difficult to combine the features of a sharp tip shape, appropriate length, and a hollow structure simultaneously. Thus, here we report a sharp, hollow, and ultrahigh aspect ratio microneedle long enough to get to the blood vessels which is capable of minimizing the pain caused by nerve pricking. It is equipped with a fluidic system to handle blood. The structure of the microneedle was precisely formed using a drawing lithography method and a sharp angle tip was formed using a laser-cutting method.",
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A three-dimensional and bevel-angled ultrahigh aspect ratio microneedle for minimally invasive and painless blood sampling. / Lee, Dae Sik; Li, Cheng Guo; Ihm, Chunhwa; Jung, Hyungil.

In: Sensors and Actuators, B: Chemical, Vol. 255, 01.02.2018, p. 384-390.

Research output: Contribution to journalArticle

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