A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy

Yeon Sik Choi, Hyoyoung Jeong, Rose T. Yin, Raudel Avila, Anna Pfenniger, Jaeyoung Yoo, Jong Yoon Lee, Andreas Tzavelis, Young Joong Lee, Sheena W. Chen, Helen S. Knight, Seungyeob Kim, Hak Young Ahn, Grace Wickerson, Abraham Vázquez-Guardado, Elizabeth Higbee-Dempsey, Bender A. Russo, Michael A. Napolitano, Timothy J. Holleran, Leen Abdul RazzakAlana N. Miniovich, Geumbee Lee, Beth Geist, Brandon Kim, Shuling Han, Jaclyn A. Brennan, Kedar Aras, Sung Soo Kwak, Joohee Kim, Emily Alexandria Waters, Xiangxing Yang, Amy Burrell, Keum San Chun, Claire Liu, Changsheng Wu, Alina Y. Rwei, Alisha N. Spann, Anthony Banks, David Johnson, Zheng Jenny Zhang, Chad R. Haney, Sung Hun Jin, Alan Varteres Sahakian, Yonggang Huang, Gregory D. Trachiotis, Bradley P. Knight, Rishi K. Arora, Igor R. Efimov, John A. Rogers

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. We present a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden. The result provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices.

Original languageEnglish
Pages (from-to)1006-1012
Number of pages7
JournalScience
Volume376
Issue number6596
DOIs
Publication statusPublished - 2022 May 27

Bibliographical note

Funding Information:
This work was funded by National Institutes of Health grants 1K99HL155844-01A1 (Y.S.C.), R01-HL141470 (I.R.E. and J.A.R.), R01 HL140061 (R.K.A.), R01 HL125881 (R.K.A.), KL2TR001424 (A.P.), F30HL157066 (A.T.), and 5K99-HL148523-02 (K.A.); Ministry of Health & Welfare, Republic of Korea (Korea Health Industry Development Institute), grant HI19C1348 (Y.S.C. and H.-Y.A.); Leducq Foundation project RHYTHM (I.R.E. and J.A.R.); American Heart Association 18SFRN34110170 (R.K.A.); American Heart Association Predoctoral Fellowship 19PRE34380781 (R.T.Y.); National Science Foundation Graduate Research Fellowship 1842165 (R.A.); a Ford Foundation Predoctoral Fellowship (R.A.); Chan Zuckerberg Initiative DAF grant 2020-225578 (E.A.W.); and an advised fund of the Silicon Valley Community Foundation (E A W)

Publisher Copyright:
© 2022 American Association for the Advancement of Science. All rights reserved.

All Science Journal Classification (ASJC) codes

  • General

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