A triple-targeting delivery system carrying two anticancer agents

Hui Li; Chang Hee Lee; Injae Shin

doi:10.1039/d1ob01089a

A triple-targeting delivery system carrying two anticancer agents

Hui Li, Chang Hee Lee, Injae Shin

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

To improve tumor selectivity, a triple-targeting delivery system (Oct-FK(PBA-Az)-Dox) carrying two anticancer agents (apoptozole (Az) and doxorubicin (Dox)) was designed and synthesized. The results showed that both anticancer agents in Oct-FK(PBA-Az)-Dox are liberated in the presence of both H₂O₂and cathepsin B, which are normally present at high levels in tumors.

Original language	English
Pages (from-to)	8009-8013
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	19
Issue number	37
DOIs	https://doi.org/10.1039/d1ob01089a
Publication status	Published - 2021 Oct 7

Bibliographical note

Funding Information:
This study was supported financially by the National Research Foundation of Korea (grant no. 2020R1A2C3003462).

Publisher Copyright:
© The Royal Society of Chemistry 2021.

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/d1ob01089a

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title = "A triple-targeting delivery system carrying two anticancer agents",

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author = "Hui Li and Lee, {Chang Hee} and Injae Shin",

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AU - Lee, Chang Hee

AU - Shin, Injae

N1 - Funding Information: This study was supported financially by the National Research Foundation of Korea (grant no. 2020R1A2C3003462). Publisher Copyright: © The Royal Society of Chemistry 2021.

PY - 2021/10/7

Y1 - 2021/10/7

N2 - To improve tumor selectivity, a triple-targeting delivery system (Oct-FK(PBA-Az)-Dox) carrying two anticancer agents (apoptozole (Az) and doxorubicin (Dox)) was designed and synthesized. The results showed that both anticancer agents in Oct-FK(PBA-Az)-Dox are liberated in the presence of both H2O2and cathepsin B, which are normally present at high levels in tumors.

AB - To improve tumor selectivity, a triple-targeting delivery system (Oct-FK(PBA-Az)-Dox) carrying two anticancer agents (apoptozole (Az) and doxorubicin (Dox)) was designed and synthesized. The results showed that both anticancer agents in Oct-FK(PBA-Az)-Dox are liberated in the presence of both H2O2and cathepsin B, which are normally present at high levels in tumors.

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A triple-targeting delivery system carrying two anticancer agents

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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