A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients

Seok Kang Eun, Soo Kim Myoung, Seun Kim Yu, Yeon Hur Kyu, Jin Han Seung, Mo Nam Chung, Woo Ahn Chul, Soo Cha Bong, Il Kim Soon, Chul Lee Hyun

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE- Posttransplantation diabetes mellitus (PTDM) is a major complication associated with kidney transplantation. Defects in insulin secretion play a pivotal role in the pathogenesis of PTDM. A polymorphism in the transcription factor 7-like 2 (TCF7L2) gene was reported to be associated with type 2 diabetes and possibly associated with an insulin secretion defect. The aim of this study was to investigate the association between genetic variations in TCF7L2 and PTDM in renal allograft recipients. RESEARCH DESIGN AND METHODS- A total of 511 unrelated renal allograft recipients without previously known diabetes were enrolled. Six single nucleotide polymorphisms (rs11196205, rs4506565, rs12243326, rs7903146, rs12255372, and rs7901695) were genotyped in the cohort, which consisted of 119 PTDM patients and 392 non-PTDM subjects. The genotyping of TCF7L2 polymorphisms was performed using real-time PCR. RESULTS- rs4506565, rs7901695, and rs7903146 were found to be in complete linkage disequilibrium. The rs7903146 genotype distribution was CC 94.3% and CT 5.7%. The incidence of PTDM was significantly higher in patients with the CT genotype than in patients with the CC genotype (41.4 vs. 22.2%) (odds ratio 2.474 [95% CI 1.146-5.341]; P = 0.024). The effect of this genotype remains significant after adjustment for age, sex, amount of body weight gain, and type of immunosuppressant (2.655 [1.168-6.038]; P = 0.020). CONCLUSIONS- These data suggest that the TCF7L2 rs7903146 genetic variation is associated with an increased risk of PTDM in renal allograft recipients.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalDiabetes Care
Volume31
Issue number1
DOIs
Publication statusPublished - 2008 Jan 1

Fingerprint

T Cell Transcription Factor 1
Allografts
Diabetes Mellitus
Kidney
Genes
Genotype
Insulin
Somatotypes
Linkage Disequilibrium
Immunosuppressive Agents
Kidney Transplantation
Type 2 Diabetes Mellitus
Weight Gain
Single Nucleotide Polymorphism
Real-Time Polymerase Chain Reaction
Research Design
Odds Ratio
Body Weight

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Eun, Seok Kang ; Myoung, Soo Kim ; Yu, Seun Kim ; Kyu, Yeon Hur ; Seung, Jin Han ; Chung, Mo Nam ; Chul, Woo Ahn ; Bong, Soo Cha ; Soon, Il Kim ; Hyun, Chul Lee. / A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients. In: Diabetes Care. 2008 ; Vol. 31, No. 1. pp. 63-68.
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title = "A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients",
abstract = "OBJECTIVE- Posttransplantation diabetes mellitus (PTDM) is a major complication associated with kidney transplantation. Defects in insulin secretion play a pivotal role in the pathogenesis of PTDM. A polymorphism in the transcription factor 7-like 2 (TCF7L2) gene was reported to be associated with type 2 diabetes and possibly associated with an insulin secretion defect. The aim of this study was to investigate the association between genetic variations in TCF7L2 and PTDM in renal allograft recipients. RESEARCH DESIGN AND METHODS- A total of 511 unrelated renal allograft recipients without previously known diabetes were enrolled. Six single nucleotide polymorphisms (rs11196205, rs4506565, rs12243326, rs7903146, rs12255372, and rs7901695) were genotyped in the cohort, which consisted of 119 PTDM patients and 392 non-PTDM subjects. The genotyping of TCF7L2 polymorphisms was performed using real-time PCR. RESULTS- rs4506565, rs7901695, and rs7903146 were found to be in complete linkage disequilibrium. The rs7903146 genotype distribution was CC 94.3{\%} and CT 5.7{\%}. The incidence of PTDM was significantly higher in patients with the CT genotype than in patients with the CC genotype (41.4 vs. 22.2{\%}) (odds ratio 2.474 [95{\%} CI 1.146-5.341]; P = 0.024). The effect of this genotype remains significant after adjustment for age, sex, amount of body weight gain, and type of immunosuppressant (2.655 [1.168-6.038]; P = 0.020). CONCLUSIONS- These data suggest that the TCF7L2 rs7903146 genetic variation is associated with an increased risk of PTDM in renal allograft recipients.",
author = "Eun, {Seok Kang} and Myoung, {Soo Kim} and Yu, {Seun Kim} and Kyu, {Yeon Hur} and Seung, {Jin Han} and Chung, {Mo Nam} and Chul, {Woo Ahn} and Bong, {Soo Cha} and Soon, {Il Kim} and Hyun, {Chul Lee}",
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A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients. / Eun, Seok Kang; Myoung, Soo Kim; Yu, Seun Kim; Kyu, Yeon Hur; Seung, Jin Han; Chung, Mo Nam; Chul, Woo Ahn; Bong, Soo Cha; Soon, Il Kim; Hyun, Chul Lee.

In: Diabetes Care, Vol. 31, No. 1, 01.01.2008, p. 63-68.

Research output: Contribution to journalArticle

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T1 - A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients

AU - Eun, Seok Kang

AU - Myoung, Soo Kim

AU - Yu, Seun Kim

AU - Kyu, Yeon Hur

AU - Seung, Jin Han

AU - Chung, Mo Nam

AU - Chul, Woo Ahn

AU - Bong, Soo Cha

AU - Soon, Il Kim

AU - Hyun, Chul Lee

PY - 2008/1/1

Y1 - 2008/1/1

N2 - OBJECTIVE- Posttransplantation diabetes mellitus (PTDM) is a major complication associated with kidney transplantation. Defects in insulin secretion play a pivotal role in the pathogenesis of PTDM. A polymorphism in the transcription factor 7-like 2 (TCF7L2) gene was reported to be associated with type 2 diabetes and possibly associated with an insulin secretion defect. The aim of this study was to investigate the association between genetic variations in TCF7L2 and PTDM in renal allograft recipients. RESEARCH DESIGN AND METHODS- A total of 511 unrelated renal allograft recipients without previously known diabetes were enrolled. Six single nucleotide polymorphisms (rs11196205, rs4506565, rs12243326, rs7903146, rs12255372, and rs7901695) were genotyped in the cohort, which consisted of 119 PTDM patients and 392 non-PTDM subjects. The genotyping of TCF7L2 polymorphisms was performed using real-time PCR. RESULTS- rs4506565, rs7901695, and rs7903146 were found to be in complete linkage disequilibrium. The rs7903146 genotype distribution was CC 94.3% and CT 5.7%. The incidence of PTDM was significantly higher in patients with the CT genotype than in patients with the CC genotype (41.4 vs. 22.2%) (odds ratio 2.474 [95% CI 1.146-5.341]; P = 0.024). The effect of this genotype remains significant after adjustment for age, sex, amount of body weight gain, and type of immunosuppressant (2.655 [1.168-6.038]; P = 0.020). CONCLUSIONS- These data suggest that the TCF7L2 rs7903146 genetic variation is associated with an increased risk of PTDM in renal allograft recipients.

AB - OBJECTIVE- Posttransplantation diabetes mellitus (PTDM) is a major complication associated with kidney transplantation. Defects in insulin secretion play a pivotal role in the pathogenesis of PTDM. A polymorphism in the transcription factor 7-like 2 (TCF7L2) gene was reported to be associated with type 2 diabetes and possibly associated with an insulin secretion defect. The aim of this study was to investigate the association between genetic variations in TCF7L2 and PTDM in renal allograft recipients. RESEARCH DESIGN AND METHODS- A total of 511 unrelated renal allograft recipients without previously known diabetes were enrolled. Six single nucleotide polymorphisms (rs11196205, rs4506565, rs12243326, rs7903146, rs12255372, and rs7901695) were genotyped in the cohort, which consisted of 119 PTDM patients and 392 non-PTDM subjects. The genotyping of TCF7L2 polymorphisms was performed using real-time PCR. RESULTS- rs4506565, rs7901695, and rs7903146 were found to be in complete linkage disequilibrium. The rs7903146 genotype distribution was CC 94.3% and CT 5.7%. The incidence of PTDM was significantly higher in patients with the CT genotype than in patients with the CC genotype (41.4 vs. 22.2%) (odds ratio 2.474 [95% CI 1.146-5.341]; P = 0.024). The effect of this genotype remains significant after adjustment for age, sex, amount of body weight gain, and type of immunosuppressant (2.655 [1.168-6.038]; P = 0.020). CONCLUSIONS- These data suggest that the TCF7L2 rs7903146 genetic variation is associated with an increased risk of PTDM in renal allograft recipients.

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