A versatile approach to oligostilbenoid natural products - Synthesis of permethylated analogues of viniferifuran, malibatol A, and shoreaphenol

Ikyon Kim, Jihyun Choi

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

A highly practical route to oligostilbenoid natural products is described. A regioselective Bi(OTf)3-catalyzed cyclodehydration provided ready access to 3-arylbenzofuran. Pd-catalyzed direct C-H activation of benzofuran and subsequent cross-coupling with aryl halide was successfully implemented for the introduction of aryl group at the C2 position of benzofuran. Further manipulation of the 2,3-diarylbenzofuran led to the efficient total synthesis of permethylated analogues of viniferifuran, malibatol A, and shoreaphenol.

Original languageEnglish
Pages (from-to)2788-2795
Number of pages8
JournalOrganic and Biomolecular Chemistry
Volume7
Issue number13
DOIs
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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